Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1666608..1667038 Replicon chromosome
Accession NZ_AP017305
Organism Fischerella sp. NIES-3754

Toxin (Protein)


Gene name hicA Uniprot ID A0A0S3TKI4
Locus tag FIS3754_RS07195 Protein ID WP_062245599.1
Coordinates 1666608..1666832 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID A0A0S3TKJ6
Locus tag FIS3754_RS07200 Protein ID WP_062245602.1
Coordinates 1666829..1667038 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIS3754_RS07180 1662279..1663262 - 984 WP_062245593.1 alpha-ketoacid dehydrogenase subunit beta -
FIS3754_RS07185 1663692..1664000 - 309 WP_009459051.1 helix-turn-helix transcriptional regulator -
FIS3754_RS07190 1664509..1666509 + 2001 WP_062245596.1 cation:proton antiporter -
FIS3754_RS07195 1666608..1666832 - 225 WP_062245599.1 type II toxin-antitoxin system HicA family toxin Toxin
FIS3754_RS07200 1666829..1667038 - 210 WP_062245602.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FIS3754_RS07205 1667414..1668394 - 981 WP_009459046.1 porphobilinogen synthase -
FIS3754_RS07210 1668871..1669212 - 342 WP_062245604.1 DUF4870 domain-containing protein -
FIS3754_RS07215 1669418..1671049 + 1632 WP_062245606.1 peptide chain release factor 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-51)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8514.82 Da        Isoelectric Point: 7.4051

>T31057 WP_062245599.1 NZ_AP017305:c1666832-1666608 [Fischerella sp. NIES-3754]
MINIPVLKPQEVVRILESLGFVEVRQKGSHKQFRHEDGRGTTVPFHKERDISPKLLRQIANDIGLSVEEMLESH

Download         Length: 225 bp

>T31057 NZ_AP017305:c1666832-1666608 [Fischerella sp. NIES-3754]
ATGATCAATATTCCCGTCCTGAAGCCACAAGAGGTTGTTCGTATTCTAGAGAGCCTTGGTTTTGTAGAAGTGCGCCAGAA
GGGTTCGCACAAGCAATTTCGCCACGAAGATGGTCGAGGGACAACCGTTCCATTTCACAAAGAGCGTGATATTTCACCGA
AACTGCTACGCCAGATTGCAAATGATATTGGTTTGTCTGTTGAAGAAATGCTGGAGTCGCACTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7855.82 Da        Isoelectric Point: 3.8343

>AT31057 WP_062245602.1 NZ_AP017305:c1667038-1666829 [Fischerella sp. NIES-3754]
MKTFTAIIERDPDTNLYVGYVPGFPGAHSQGETLDELQENLREVIEMLLEDREVVFETEFVGTQQIVVP

Download         Length: 210 bp

>AT31057 NZ_AP017305:c1667038-1666829 [Fischerella sp. NIES-3754]
ATGAAAACCTTCACCGCAATTATTGAGCGTGATCCTGACACAAATCTGTACGTCGGTTATGTTCCTGGGTTCCCTGGAGC
GCATTCTCAAGGAGAAACCTTAGATGAATTACAAGAGAATCTTCGTGAAGTGATTGAGATGCTTTTAGAGGATAGAGAAG
TGGTATTCGAGACGGAATTTGTGGGTACACAACAGATTGTAGTTCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3TKI4

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3TKJ6

References