31050

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 202604..203109 Replicon chromosome
Accession NZ_AP017302
Organism Pseudomonas aeruginosa strain IOMTU 133

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag IOMTU133_RS00935 Protein ID WP_003083773.1
Coordinates 202604..202885 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag IOMTU133_RS00940 Protein ID WP_003137009.1
Coordinates 202882..203109 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOMTU133_RS00910 197855..199204 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
IOMTU133_RS00915 199253..199939 + 687 WP_003083762.1 FadR family transcriptional regulator -
IOMTU133_RS00920 200040..200774 + 735 WP_003110658.1 GntR family transcriptional regulator -
IOMTU133_RS00925 200978..201364 + 387 WP_003083767.1 aegerolysin family protein -
IOMTU133_RS00930 201396..202304 - 909 WP_060852951.1 LysR family transcriptional regulator -
IOMTU133_RS00935 202604..202885 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
IOMTU133_RS00940 202882..203109 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
IOMTU133_RS00945 203285..203905 - 621 WP_003101226.1 hypothetical protein -
IOMTU133_RS00950 204006..204506 + 501 WP_003162763.1 LEA type 2 family protein -
IOMTU133_RS00955 204579..204920 + 342 WP_003101229.1 alkylphosphonate utilization protein -
IOMTU133_RS00960 205002..206429 - 1428 WP_003083784.1 GABA permease -
IOMTU133_RS00965 206598..208091 - 1494 WP_023112601.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T31050 WP_003083773.1 NZ_AP017302:c202885-202604 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T31050 NZ_AP017302:c202885-202604 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT31050 WP_003137009.1 NZ_AP017302:c203109-202882 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp

>AT31050 NZ_AP017302:c203109-202882 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6XRW


Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References