Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 1775132..1775706 Replicon chromosome
Accession NZ_AP017295
Organism Nostoc sp. NIES-3756

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag NOS3756_RS07410 Protein ID WP_082727171.1
Coordinates 1775132..1775476 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID -
Locus tag NOS3756_RS07415 Protein ID WP_067766607.1
Coordinates 1775470..1775706 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOS3756_RS07395 1771511..1773124 - 1614 WP_067766594.1 NAD(P)H-quinone oxidoreductase subunit 4 -
NOS3756_RS07400 1773414..1773953 - 540 WP_067766598.1 hypothetical protein -
NOS3756_RS07405 1774030..1774935 - 906 WP_067766601.1 homoserine kinase -
NOS3756_RS07410 1775132..1775476 - 345 WP_082727171.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NOS3756_RS07415 1775470..1775706 - 237 WP_067766607.1 hypothetical protein Antitoxin
NOS3756_RS07420 1775879..1776604 - 726 WP_067766609.1 hypothetical protein -
NOS3756_RS07425 1776723..1778570 - 1848 WP_067766611.1 threonine--tRNA ligase -
NOS3756_RS07430 1779034..1779351 + 318 WP_067766614.1 DUF2605 domain-containing protein -
NOS3756_RS07435 1779596..1779940 + 345 WP_067766616.1 DUF2973 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12902.94 Da        Isoelectric Point: 4.5994

>T31047 WP_082727171.1 NZ_AP017295:c1775476-1775132 [Nostoc sp. NIES-3756]
MVMYRGEIWWANLPDTLGSEPGYRRPVLIIQDDTFNHSRISTVIVVIITSNIQLAEAPGNVLLPRETSGLPKNSVVNVSQ
ILTIDKRFLIERIGALPDYLQEEVDEGLRIILYL

Download         Length: 345 bp

>T31047 NZ_AP017295:c1775476-1775132 [Nostoc sp. NIES-3756]
TTGGTAATGTATCGGGGAGAAATTTGGTGGGCAAATCTACCTGATACATTAGGTTCTGAACCAGGTTATCGCCGTCCTGT
TTTAATAATTCAAGACGATACATTTAATCACAGCCGTATTAGTACAGTAATAGTCGTAATTATTACATCAAATATTCAAT
TGGCGGAAGCCCCTGGCAACGTATTGTTACCCCGTGAGACATCGGGTTTACCTAAAAATTCTGTTGTTAACGTATCTCAA
ATTCTCACTATTGATAAAAGGTTCTTGATTGAACGTATCGGAGCATTACCAGATTACTTGCAAGAGGAAGTTGATGAAGG
ACTAAGAATAATCTTGTACCTTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8976.14 Da        Isoelectric Point: 4.3611

>AT31047 WP_067766607.1 NZ_AP017295:c1775706-1775470 [Nostoc sp. NIES-3756]
MKTAISLPDSVFEEAEALAKQLGLSRSELYTKALQAYLQKYNHNQILDKLNEVYSQESSELDPVLARMQFLSLPQEDW

Download         Length: 237 bp

>AT31047 NZ_AP017295:c1775706-1775470 [Nostoc sp. NIES-3756]
ATGAAAACTGCTATTTCATTACCAGATTCAGTTTTTGAAGAAGCAGAAGCACTGGCAAAACAGTTAGGTTTATCACGCAG
TGAATTGTATACCAAGGCATTACAAGCGTATCTACAAAAGTACAACCATAATCAAATTCTCGATAAGCTGAACGAAGTTT
ATTCTCAAGAATCTTCTGAACTAGATCCCGTTTTGGCAAGGATGCAATTTCTGTCTCTGCCGCAAGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References