Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 985520..986326 Replicon chromosome
Accession NZ_AP014956
Organism Staphylococcus capitis strain TW2795

Toxin (Protein)


Gene name tsbT Uniprot ID A0A1J4EAU5
Locus tag JMUB0001_RS04850 Protein ID WP_002434789.1
Coordinates 986147..986326 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A1J4ECT8
Locus tag JMUB0001_RS04845 Protein ID WP_002453580.1
Coordinates 985520..986119 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMUB0001_RS04825 981409..982866 + 1458 WP_002469724.1 ABC transporter substrate-binding protein/permease -
JMUB0001_RS04830 982859..983581 + 723 WP_064212285.1 amino acid ABC transporter ATP-binding protein -
JMUB0001_RS04835 983704..984867 + 1164 WP_087671673.1 tRNA epoxyqueuosine(34) reductase QueG -
JMUB0001_RS04840 984870..985340 + 471 WP_023350044.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
JMUB0001_RS04845 985520..986119 + 600 WP_002453580.1 glucosamine-6-phosphate isomerase Antitoxin
JMUB0001_RS04850 986147..986326 + 180 WP_002434789.1 hypothetical protein Toxin
JMUB0001_RS04855 986491..986889 + 399 WP_049428016.1 hypothetical protein -
JMUB0001_RS04860 987043..988428 + 1386 WP_002434798.1 class II fumarate hydratase -
JMUB0001_RS04865 988526..989356 - 831 WP_096389217.1 RluA family pseudouridine synthase -
JMUB0001_RS04870 989532..990644 + 1113 WP_037549760.1 GAF domain-containing sensor histidine kinase -
JMUB0001_RS04875 990664..991287 + 624 WP_002434769.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 7005.38 Da        Isoelectric Point: 3.9242

>T31040 WP_002434789.1 NZ_AP014956:986147-986326 [Staphylococcus capitis]
MNKEHESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVRSDLNNE

Download         Length: 180 bp

>T31040 NZ_AP014956:986147-986326 [Staphylococcus capitis]
ATGAATAAAGAACATGAATCTAAATTGAATTATCATGAAGAAGAAAATGCTATGGTTACAGATTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAAATTTCAGAAGAAAATGATGAAGATAAATTAAACCAATCTCATGATGAAGATGTTCGTT
CTGACCTTAATAATGAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22720.63 Da        Isoelectric Point: 4.7928

>AT31040 WP_002453580.1 NZ_AP014956:985520-986119 [Staphylococcus capitis]
MAMNFKVFENSERVAEYAADIIRKQFNNNPTTIAGFHLEKDHAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEQDAIDFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKREVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARYV

Download         Length: 600 bp

>AT31040 NZ_AP014956:985520-986119 [Staphylococcus capitis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAGTGAAAGAGTAGCAGAATATGCTGCAGATATTATTCGTAAACAATTTAA
TAATAATCCAACTACAATTGCAGGTTTTCACTTAGAAAAAGATCACGCACCTGTATTAGATGAACTTAAGAAAAATGTAG
ATACGCATGCTGTAGATTTCAGCCAAATCAATATTTTAGATTATGATGATAATAGATCTTATTATGAAGCATTAGGTGTA
CCTGAAAGCCAAGTGTATTCAATTTCTTACGAACAAGATGCAATTGATTTTATTTCAGATAAAATGAAAACTAAAGAAAA
TAAAGGTAAATTAATCCTTCAAGTTCTTTCAATTGATGAAAGTGGCAAGTTAGATGTAAGTGTACGTCAAGGTCTTATGG
AAGCTAGAGAAATTTTCTTAGTTGTTACAGGTAGTAATAAACGTGAAGTTATTGAAAAACTTTATCGTGAAAACGGTAAA
TCTAGTTATGAGCCAGCAGATCTTAAAGCACACCGCATGGTAAATGTTATTTTAGATAAAGAAGCGGCTGCAGGATTACC
TGAGGATGTTAAAGAATACTTCACAGCACGTTATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4EAU5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4ECT8

References