Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 843534..844057 Replicon chromosome
Accession NZ_AP014956
Organism Staphylococcus capitis strain TW2795

Toxin (Protein)


Gene name mazF Uniprot ID A0A1J4E8Y2
Locus tag JMUB0001_RS04050 Protein ID WP_002435799.1
Coordinates 843701..844057 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1J4E747
Locus tag JMUB0001_RS04045 Protein ID WP_002435513.1
Coordinates 843534..843704 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMUB0001_RS04020 839361..839840 + 480 WP_096389183.1 PH domain-containing protein -
JMUB0001_RS04025 839833..841332 + 1500 WP_070597718.1 PH domain-containing protein -
JMUB0001_RS04030 841325..841825 + 501 WP_049427301.1 PH domain-containing protein -
JMUB0001_RS04035 841874..842230 + 357 WP_002435510.1 holo-ACP synthase -
JMUB0001_RS04040 842297..843445 + 1149 WP_049427304.1 alanine racemase -
JMUB0001_RS04045 843534..843704 + 171 WP_002435513.1 hypothetical protein Antitoxin
JMUB0001_RS04050 843701..844057 + 357 WP_002435799.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JMUB0001_RS04055 844436..845437 + 1002 WP_002453685.1 PP2C family protein-serine/threonine phosphatase -
JMUB0001_RS04060 845539..845865 + 327 WP_002435753.1 anti-sigma factor antagonist -
JMUB0001_RS04065 845867..846346 + 480 WP_002435518.1 anti-sigma B factor RsbW -
JMUB0001_RS04070 846321..847091 + 771 WP_002435824.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13327.44 Da        Isoelectric Point: 9.8770

>T31039 WP_002435799.1 NZ_AP014956:843701-844057 [Staphylococcus capitis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHQ

Download         Length: 357 bp

>T31039 NZ_AP014956:843701-844057 [Staphylococcus capitis]
ATGATTAGAAGAGGCGATGTTTACTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTTGT
AATTATACAAAATGATACTGGTAATAAATATAGTCCAACTGTCATAGTTGCTGCTATTACAGGTAGGATTAATAAAGCGA
AGATACCAACCCATGTAGAAATTGAAAAGAAAAAATATAAGTTAGATAAAGACTCTGTTATCTTACTTGAACAAATTAGA
ACACTAGATAAAAAACGTTTAAAAGAGAAGTTGACCTATTTGTCTGAAAGTAAGATGAAGGAAGTTGACAACGCCCTAGA
TATCAGTCTAGGATTACATAATTTTGACCATCAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6263.87 Da        Isoelectric Point: 4.0121

>AT31039 WP_002435513.1 NZ_AP014956:843534-843704 [Staphylococcus capitis]
MLSFNQSRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT31039 NZ_AP014956:843534-843704 [Staphylococcus capitis]
ATGTTATCTTTTAATCAATCTAGGAGTCACAGTCTTGAACAATCATTAAAAGAAGGCTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACGGAAGCTTTTCCCATCGAATGTGAAGCTTGCGATTGTAATGAAACATATCTTACTTCTAACTCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E8Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E747

References