Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 832498..833012 Replicon chromosome
Accession NZ_AP014956
Organism Staphylococcus capitis strain TW2795

Toxin (Protein)


Gene name TsdT Uniprot ID A0A1J4E3P3
Locus tag JMUB0001_RS03990 Protein ID WP_023351364.1
Coordinates 832806..833012 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1J4E888
Locus tag JMUB0001_RS03985 Protein ID WP_002435858.1
Coordinates 832498..832791 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMUB0001_RS03960 827656..828444 + 789 WP_002435520.1 hydroxyethylthiazole kinase -
JMUB0001_RS03965 828451..829089 + 639 WP_037551262.1 thiamine phosphate synthase -
JMUB0001_RS03970 829178..830050 + 873 WP_002435877.1 membrane protein insertase YidC -
JMUB0001_RS03975 830109..830771 - 663 WP_002453696.1 HD domain-containing protein -
JMUB0001_RS03980 830828..832312 - 1485 WP_002435854.1 cardiolipin synthase -
JMUB0001_RS03985 832498..832791 + 294 WP_002435858.1 copper-sensing transcriptional repressor CsoR Antitoxin
JMUB0001_RS03990 832806..833012 + 207 WP_023351364.1 hypothetical protein Toxin
JMUB0001_RS03995 833149..833286 + 138 WP_002435861.1 hypothetical protein -
JMUB0001_RS04000 833342..834553 - 1212 WP_064212371.1 rod shape-determining protein RodA -
JMUB0001_RS04005 834958..836028 + 1071 WP_002435813.1 D-alanine--D-alanine ligase -
JMUB0001_RS04010 836044..837399 + 1356 WP_096389181.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7821.85 Da        Isoelectric Point: 4.2087

>T31038 WP_023351364.1 NZ_AP014956:832806-833012 [Staphylococcus capitis]
MENGIVYVANIETIEEENQLKTRLENMIGVEKVDIDSKVGEIKVLFETPANLNSIEKEVYDSGFRVRY

Download         Length: 207 bp

>T31038 NZ_AP014956:832806-833012 [Staphylococcus capitis]
ATGGAAAATGGAATTGTTTATGTTGCTAATATTGAGACTATAGAGGAAGAAAACCAATTAAAGACACGTTTAGAAAATAT
GATTGGTGTCGAAAAAGTAGATATTGATAGTAAAGTAGGAGAAATAAAGGTATTATTTGAAACACCTGCGAATTTAAATA
GTATTGAAAAAGAAGTATATGATTCTGGCTTTCGCGTGCGTTATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11065.56 Da        Isoelectric Point: 6.4776

>AT31038 WP_002435858.1 NZ_AP014956:832498-832791 [Staphylococcus capitis]
VTENETAHHSEQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT31038 NZ_AP014956:832498-832791 [Staphylococcus capitis]
GTGACTGAAAATGAAACTGCACATCACTCAGAGCAAACGAAAGCAAATTTAAAGTCACGATTAAATCGTATCGAAGGTCA
AGTACGTGCAATTAATCGAATGATTGAAGACGATGTGTATTGCGATGATGTTTTAACTCAAATAAGAGCGACACGCTCTG
CTTTAAACAGTGTGGCTACTAAATTGTTAGATCATCATATGAAAAGTTGTATTATGAATAAAGTGAATAATGGTGCACAA
GAAGAAGCGATGGAAGAACTATTGGTTACTTTTCAAAAATTAATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E3P3

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E888

References