Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3521261..3521841 Replicon chromosome
Accession NZ_AP014946
Organism Variibacter gotjawalensis strain GJW-30

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GJW30_RS17165 Protein ID WP_096357490.1
Coordinates 3521261..3521449 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GJW30_RS17170 Protein ID WP_096358891.1
Coordinates 3521449..3521841 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJW30_RS17145 3516562..3517422 + 861 WP_096357484.1 DMT family transporter -
GJW30_RS17150 3517862..3519844 + 1983 WP_096358890.1 TonB-dependent siderophore receptor -
GJW30_RS17155 3520023..3520646 + 624 WP_096357486.1 glutathione S-transferase family protein -
GJW30_RS17160 3520647..3521078 - 432 WP_096357488.1 hypothetical protein -
GJW30_RS17165 3521261..3521449 + 189 WP_096357490.1 type II toxin-antitoxin system HicA family toxin Toxin
GJW30_RS17170 3521449..3521841 + 393 WP_096358891.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GJW30_RS17175 3522419..3526147 + 3729 WP_096357492.1 vitamin B12-dependent ribonucleotide reductase -
GJW30_RS17180 3526147..3526344 + 198 WP_096357494.1 KTSC domain-containing protein -
GJW30_RS22860 3526385..3526567 + 183 WP_096357496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7035.16 Da        Isoelectric Point: 11.8888

>T31036 WP_096357490.1 NZ_AP014946:3521261-3521449 [Variibacter gotjawalensis]
MNSRDVIAALRQDGWVEVAQKGSHLQFKHPSKPGRVTVPHPKRDIPLGTLRSIEKQAQLRVR

Download         Length: 189 bp

>T31036 NZ_AP014946:3521261-3521449 [Variibacter gotjawalensis]
ATGAATTCGCGCGACGTGATTGCGGCGCTTCGGCAAGATGGTTGGGTTGAGGTGGCTCAGAAGGGCAGTCACCTGCAGTT
CAAGCACCCGTCGAAGCCCGGCCGGGTCACGGTCCCGCATCCCAAGCGGGATATCCCGCTCGGAACCCTGCGAAGCATCG
AAAAACAAGCACAGCTGAGAGTGAGATGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13801.56 Da        Isoelectric Point: 4.5521

>AT31036 WP_096358891.1 NZ_AP014946:3521449-3521841 [Variibacter gotjawalensis]
MRDYIALIHKDQDSDYGVSFPDLPGCISAGKTLDEAQTMAAEALAFHLEGLALDGEPVPEPSSLQTIMSDRANRDGVAVL
VAAPQPSGRSVRVNVTLPDDLLDAIDRHAEKNGFTRSGFLAQAAKKALVA

Download         Length: 393 bp

>AT31036 NZ_AP014946:3521449-3521841 [Variibacter gotjawalensis]
ATGCGCGACTACATCGCTCTTATCCACAAAGACCAGGATAGCGACTACGGCGTTTCGTTTCCGGACCTGCCCGGCTGCAT
CAGCGCGGGCAAAACGCTCGACGAAGCGCAGACGATGGCGGCCGAAGCTTTAGCGTTCCACCTCGAAGGTCTCGCGCTCG
ATGGCGAACCTGTGCCCGAGCCGAGCTCGCTGCAGACGATCATGAGCGACCGGGCGAATCGCGACGGCGTCGCCGTCTTG
GTCGCGGCGCCTCAGCCGTCCGGCAGAAGCGTTCGCGTGAATGTCACGCTGCCGGACGATCTTCTCGACGCAATCGACCG
GCACGCGGAGAAAAACGGCTTCACGCGATCGGGTTTTCTCGCACAAGCGGCAAAGAAAGCCCTCGTCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References