Detailed information of TA system TA031036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3521261..3521841
• Replicon: chromosome
• Accession: NZ_AP014946
• Organism: Variibacter gotjawalensis strain GJW-30

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GJW30_RS17165
• Protein ID: WP_096357490.1
• Coordinates: 3521261..3521449 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GJW30_RS17170
• Protein ID: WP_096358891.1
• Coordinates: 3521449..3521841 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJW30_RS17145	3516562..3517422	+	861	WP_096357484.1	DMT family transporter	-
GJW30_RS17150	3517862..3519844	+	1983	WP_096358890.1	TonB-dependent siderophore receptor	-
GJW30_RS17155	3520023..3520646	+	624	WP_096357486.1	glutathione S-transferase family protein	-
GJW30_RS17160	3520647..3521078	-	432	WP_096357488.1	hypothetical protein	-
GJW30_RS17165	3521261..3521449	+	189	WP_096357490.1	type II toxin-antitoxin system HicA family toxin	Toxin
GJW30_RS17170	3521449..3521841	+	393	WP_096358891.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GJW30_RS17175	3522419..3526147	+	3729	WP_096357492.1	vitamin B12-dependent ribonucleotide reductase	-
GJW30_RS17180	3526147..3526344	+	198	WP_096357494.1	KTSC domain-containing protein	-
GJW30_RS22860	3526385..3526567	+	183	WP_096357496.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7035.16 Da
• Isoelectric Point: 11.8888

>T31036 WP_096357490.1 NZ_AP014946:3521261-3521449 [Variibacter gotjawalensis]
MNSRDVIAALRQDGWVEVAQKGSHLQFKHPSKPGRVTVPHPKRDIPLGTLRSIEKQAQLRVR

Nucleotide

• Length: 189 bp

>T31036 NZ_AP014946:3521261-3521449 [Variibacter gotjawalensis]
ATGAATTCGCGCGACGTGATTGCGGCGCTTCGGCAAGATGGTTGGGTTGAGGTGGCTCAGAAGGGCAGTCACCTGCAGTT
CAAGCACCCGTCGAAGCCCGGCCGGGTCACGGTCCCGCATCCCAAGCGGGATATCCCGCTCGGAACCCTGCGAAGCATCG
AAAAACAAGCACAGCTGAGAGTGAGATGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13801.56 Da
• Isoelectric Point: 4.5521

>AT31036 WP_096358891.1 NZ_AP014946:3521449-3521841 [Variibacter gotjawalensis]
MRDYIALIHKDQDSDYGVSFPDLPGCISAGKTLDEAQTMAAEALAFHLEGLALDGEPVPEPSSLQTIMSDRANRDGVAVL
VAAPQPSGRSVRVNVTLPDDLLDAIDRHAEKNGFTRSGFLAQAAKKALVA

Nucleotide

• Length: 393 bp

>AT31036 NZ_AP014946:3521449-3521841 [Variibacter gotjawalensis]
ATGCGCGACTACATCGCTCTTATCCACAAAGACCAGGATAGCGACTACGGCGTTTCGTTTCCGGACCTGCCCGGCTGCAT
CAGCGCGGGCAAAACGCTCGACGAAGCGCAGACGATGGCGGCCGAAGCTTTAGCGTTCCACCTCGAAGGTCTCGCGCTCG
ATGGCGAACCTGTGCCCGAGCCGAGCTCGCTGCAGACGATCATGAGCGACCGGGCGAATCGCGACGGCGTCGCCGTCTTG
GTCGCGGCGCCTCAGCCGTCCGGCAGAAGCGTTCGCGTGAATGTCACGCTGCCGGACGATCTTCTCGACGCAATCGACCG
GCACGCGGAGAAAAACGGCTTCACGCGATCGGGTTTTCTCGCACAAGCGGCAAAGAAAGCCCTCGTCGCCTAG