Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1340249..1340910 Replicon chromosome
Accession NZ_AP014946
Organism Variibacter gotjawalensis strain GJW-30

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GJW30_RS06475 Protein ID WP_096353179.1
Coordinates 1340503..1340910 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag GJW30_RS06470 Protein ID WP_096358694.1
Coordinates 1340249..1340506 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJW30_RS06450 1336117..1336761 - 645 WP_130364777.1 hypothetical protein -
GJW30_RS06455 1336859..1337446 - 588 WP_096353172.1 GNAT family N-acetyltransferase -
GJW30_RS06460 1337459..1338730 - 1272 WP_096353174.1 insulinase family protein -
GJW30_RS06465 1338727..1340139 - 1413 WP_096353176.1 threonine synthase -
GJW30_RS06470 1340249..1340506 + 258 WP_096358694.1 antitoxin Antitoxin
GJW30_RS06475 1340503..1340910 + 408 WP_096353179.1 type II toxin-antitoxin system VapC family toxin Toxin
GJW30_RS06480 1340907..1341644 - 738 WP_096353182.1 SURF1 family protein -
GJW30_RS06485 1341644..1342030 - 387 WP_096353185.1 DUF983 domain-containing protein -
GJW30_RS06490 1342114..1342971 - 858 WP_096353187.1 cytochrome c oxidase subunit 3 -
GJW30_RS06495 1342995..1343591 - 597 WP_096353190.1 cytochrome c oxidase assembly protein -
GJW30_RS06500 1343602..1343769 - 168 WP_172887556.1 hypothetical protein -
GJW30_RS06505 1343781..1344719 - 939 WP_096353196.1 heme o synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(8-44)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14860.28 Da        Isoelectric Point: 10.0298

>T31033 WP_096353179.1 NZ_AP014946:1340503-1340910 [Variibacter gotjawalensis]
MIQHFLDTNAAITLMNYRPGRLFARVAAAPEKSVAVSALVVHELLYGAMRSAKIELNLKRIRLFLTDIPVFPFDAEDARV
AGEVRAVLAARGTPIGPYDALIAAQAKVRNLTVITNNVREFSRVDGLRIEDWSAA

Download         Length: 408 bp

>T31033 NZ_AP014946:1340503-1340910 [Variibacter gotjawalensis]
ATGATCCAGCATTTTCTCGATACGAACGCCGCCATCACGCTCATGAACTATCGACCTGGTCGATTGTTTGCTCGCGTTGC
CGCCGCTCCCGAAAAATCCGTCGCCGTATCCGCGCTCGTCGTGCACGAACTTCTCTATGGCGCGATGCGGAGCGCGAAGA
TCGAGCTGAACCTTAAGCGCATTCGGCTTTTCTTGACCGACATCCCTGTCTTCCCGTTCGATGCCGAGGATGCGCGTGTC
GCTGGCGAGGTCCGTGCGGTTTTGGCGGCGCGCGGCACGCCAATAGGACCCTACGACGCGCTCATCGCGGCGCAAGCAAA
GGTCCGCAATCTCACCGTCATCACCAACAACGTCCGCGAATTCTCACGCGTCGACGGTTTGCGCATCGAAGACTGGAGCG
CGGCTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9637.67 Da        Isoelectric Point: 4.5098

>AT31033 WP_096358694.1 NZ_AP014946:1340249-1340506 [Variibacter gotjawalensis]
VPRTAKIFQSGNSQAVRLPKDFRFDVSEVEISRDGDAVILRPVQTREPWAGLKAAQALGFDETFSPNGREQPEEQHRPEL
DDLFE

Download         Length: 258 bp

>AT31033 NZ_AP014946:1340249-1340506 [Variibacter gotjawalensis]
GTGCCGCGTACCGCCAAAATCTTCCAATCCGGCAATTCGCAAGCCGTCCGTCTGCCGAAGGATTTTCGCTTCGACGTCAG
CGAAGTCGAGATCTCGCGCGATGGCGACGCTGTGATTCTGCGCCCGGTGCAGACACGCGAGCCATGGGCTGGACTTAAAG
CCGCGCAAGCGCTTGGATTTGACGAAACCTTTTCCCCCAATGGACGCGAACAGCCGGAAGAGCAGCATCGTCCCGAGCTC
GACGACCTGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References