Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 495066..495730 Replicon chromosome
Accession NZ_AP014946
Organism Variibacter gotjawalensis strain GJW-30

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GJW30_RS02395 Protein ID WP_096351177.1
Coordinates 495323..495730 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GJW30_RS02390 Protein ID WP_197703761.1
Coordinates 495066..495326 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJW30_RS02360 490181..490831 - 651 WP_096351165.1 CoA transferase subunit B -
GJW30_RS02365 490844..491545 - 702 WP_096351167.1 CoA transferase subunit A -
GJW30_RS02370 491791..492183 - 393 WP_096351168.1 Co2+/Mg2+ efflux protein ApaG -
GJW30_RS02375 492297..493502 + 1206 WP_096351170.1 OpgC domain-containing protein -
GJW30_RS02380 493499..494248 + 750 WP_096351171.1 SGNH/GDSL hydrolase family protein -
GJW30_RS02385 494245..495021 + 777 WP_096351173.1 SGNH/GDSL hydrolase family protein -
GJW30_RS02390 495066..495326 + 261 WP_197703761.1 antitoxin Antitoxin
GJW30_RS02395 495323..495730 + 408 WP_096351177.1 type II toxin-antitoxin system VapC family toxin Toxin
GJW30_RS02400 495731..496903 - 1173 WP_096351180.1 O-succinylhomoserine sulfhydrylase -
GJW30_RS02405 497274..498329 + 1056 WP_197703797.1 2'-deoxycytidine 5'-triphosphate deaminase -
GJW30_RS02410 498378..499196 - 819 WP_096351184.1 ion transporter -
GJW30_RS02415 499313..500119 - 807 WP_096358613.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

SpoVT-AbrB domain

(17-54)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14988.22 Da        Isoelectric Point: 9.2587

>T31031 WP_096351177.1 NZ_AP014946:495323-495730 [Variibacter gotjawalensis]
MTAPRFVLDTNTVSDLVKNPQGRVAQRLAEIGADGICVSLIVAAELRYGCAKRASMRLTERVEGVLSRLHVLPLTAPVDR
EYAEIRTDAERTGRNIGPNDLWIAAHARSLGVPLVTANEREFRTVRGLNIENWLR

Download         Length: 408 bp

>T31031 NZ_AP014946:495323-495730 [Variibacter gotjawalensis]
TTGACGGCTCCTCGATTCGTTCTCGATACGAATACGGTTTCTGACCTCGTCAAAAACCCGCAGGGTCGTGTCGCTCAACG
ACTGGCAGAGATCGGAGCGGACGGCATTTGTGTAAGCCTCATCGTGGCCGCCGAATTAAGGTACGGCTGCGCAAAGCGCG
CATCAATGCGGTTGACCGAGCGTGTCGAAGGTGTGCTTAGCCGCCTACATGTACTCCCACTGACTGCGCCGGTTGATCGC
GAATATGCCGAGATCAGAACCGACGCCGAGCGAACAGGACGAAACATCGGCCCTAACGATCTTTGGATCGCTGCACATGC
ACGTTCCCTCGGTGTCCCATTGGTCACCGCAAACGAACGAGAGTTTCGAACCGTTCGCGGACTAAACATCGAAAATTGGC
TGCGCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9785.27 Da        Isoelectric Point: 4.4978

>AT31031 WP_197703761.1 NZ_AP014946:495066-495326 [Variibacter gotjawalensis]
MPNRCMANVQSRHVKLFRNNRNQAVRIPVEFELPGDEAIITRDGDKLIIEPVKKSGLLAYLATLEPLDEDFPDVDESLLP
LKDIEL

Download         Length: 261 bp

>AT31031 NZ_AP014946:495066-495326 [Variibacter gotjawalensis]
ATGCCAAACAGGTGTATGGCAAATGTCCAGAGTCGTCATGTCAAACTTTTCAGAAATAACCGCAATCAAGCGGTGCGGAT
TCCGGTTGAGTTCGAACTCCCGGGAGACGAGGCCATCATCACGCGCGACGGCGACAAGCTGATCATCGAGCCGGTGAAAA
AGTCTGGGTTGCTTGCCTATCTGGCAACACTCGAACCTCTCGATGAGGATTTTCCAGATGTCGACGAGAGTCTGCTACCG
CTCAAGGATATAGAGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References