Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 470074..470662 Replicon chromosome
Accession NZ_AP014946
Organism Variibacter gotjawalensis strain GJW-30

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GJW30_RS02260 Protein ID WP_096351119.1
Coordinates 470372..470662 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GJW30_RS02255 Protein ID WP_197703795.1
Coordinates 470074..470361 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJW30_RS02235 465198..466010 - 813 WP_096351104.1 transglycosylase SLT domain-containing protein -
GJW30_RS02240 466123..467352 - 1230 WP_096351107.1 FAD-dependent oxidoreductase -
GJW30_RS02245 467419..468597 - 1179 WP_096351110.1 4-hydroxybenzoate 3-monooxygenase -
GJW30_RS02250 468773..470077 + 1305 WP_096351113.1 nicotinate phosphoribosyltransferase -
GJW30_RS02255 470074..470361 - 288 WP_197703795.1 putative addiction module antidote protein Antitoxin
GJW30_RS02260 470372..470662 - 291 WP_096351119.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJW30_RS02265 470715..471482 - 768 WP_096358609.1 ATP-binding cassette domain-containing protein -
GJW30_RS02270 471491..472264 - 774 WP_157746675.1 ABC transporter permease subunit -
GJW30_RS02275 472254..473225 - 972 WP_096351125.1 ABC transporter substrate-binding protein -
GJW30_RS02280 473502..474359 + 858 WP_096351128.1 alpha/beta hydrolase -
GJW30_RS02285 474390..475199 + 810 WP_096351130.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(2-89)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11096.86 Da        Isoelectric Point: 9.9208

>T31030 WP_096351119.1 NZ_AP014946:c470662-470372 [Variibacter gotjawalensis]
MFEVVQTERFTDWLDHLKEFTAAVRIITKLRRIELGNLGDAKSVGEGVSELRIDYGPGYRIYFTQRGRKLIVLLCGGDKK
SQRRDIELAQRIAKEI

Download         Length: 291 bp

>T31030 NZ_AP014946:c470662-470372 [Variibacter gotjawalensis]
ATGTTCGAGGTCGTCCAAACCGAGCGTTTCACGGATTGGCTCGACCACCTCAAGGAATTCACAGCAGCCGTTCGCATCAT
CACGAAGCTTCGTCGCATCGAACTCGGAAATCTGGGCGACGCGAAGTCAGTCGGCGAAGGTGTGAGCGAGCTTCGCATCG
ACTACGGGCCTGGCTATCGCATCTACTTCACACAGCGCGGCCGGAAGCTCATCGTTTTGCTCTGTGGCGGGGACAAAAAA
TCGCAGCGGCGCGATATCGAACTCGCTCAGCGCATCGCGAAGGAGATCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10264.87 Da        Isoelectric Point: 10.4670

>AT31030 WP_197703795.1 NZ_AP014946:c470361-470074 [Variibacter gotjawalensis]
MKTTKFDVQHHLKTIKQQIAYLEAALDEDDATFIAAALGDVAKARGVTAFARETGLSREAIYKAFRPGGNPTIETVNKAL
RALGLRLKLAPARAA

Download         Length: 288 bp

>AT31030 NZ_AP014946:c470361-470074 [Variibacter gotjawalensis]
TTGAAGACCACGAAATTCGACGTTCAGCATCATCTTAAGACGATCAAACAACAGATCGCCTATCTCGAAGCGGCGCTGGA
CGAAGACGATGCGACCTTTATCGCTGCTGCGCTCGGCGACGTCGCGAAAGCGCGCGGCGTGACGGCCTTTGCGCGCGAGA
CGGGACTGAGCCGCGAGGCGATCTACAAAGCGTTTCGTCCCGGCGGAAATCCGACAATCGAGACTGTCAACAAAGCGCTG
CGGGCACTCGGCCTTCGGTTGAAGCTCGCGCCGGCTAGAGCGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References