Detailed information of TA system TA031017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 847716..848248
• Replicon: chromosome
• Accession: NZ_AP014942
• Organism: Staphylococcus aureus strain FDA209P

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q8VLW9
• Locus tag: SAFDA_RS04145
• Protein ID: WP_001103944.1
• Coordinates: 847928..848248 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: SAFDA_RS04140
• Protein ID: WP_001058492.1
• Coordinates: 847716..847925 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAFDA_RS04105	843233..844453	-	1221	WP_000264181.1	site-specific integrase	-
SAFDA_RS04110	844541..845269	-	729	WP_042727546.1	staphylococcal enterotoxin type K	-
SAFDA_RS04115	845293..846021	-	729	WP_001033317.1	staphylococcal enterotoxin type Q	-
SAFDA_RS04120	846196..846930	-	735	WP_000142630.1	helix-turn-helix domain-containing protein	-
SAFDA_RS04125	847080..847292	+	213	WP_001063624.1	helix-turn-helix transcriptional regulator	-
SAFDA_RS04130	847293..847565	+	273	WP_001138298.1	helix-turn-helix domain-containing protein	-
SAFDA_RS04135	847577..847723	+	147	WP_012990927.1	hypothetical protein	-
SAFDA_RS04140	847716..847925	+	210	WP_001058492.1	hypothetical protein	Antitoxin
SAFDA_RS04145	847928..848248	+	321	WP_001103944.1	DUF1474 family protein	Toxin
SAFDA_RS04150	848315..849184	+	870	WP_042727545.1	primase alpha helix C-terminal domain-containing protein	-
SAFDA_RS04155	849201..850658	+	1458	WP_042727544.1	virulence-associated E family protein	-
SAFDA_RS04160	850960..851322	+	363	WP_042727543.1	hypothetical protein	-
SAFDA_RS04165	851324..851608	+	285	WP_042727542.1	hypothetical protein	-
SAFDA_RS04170	851605..852246	+	642	WP_042727541.1	pathogenicity island protein	-
SAFDA_RS04175	852820..853161	+	342	WP_042727540.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	clfA / vWbp / selk / selq	812555..857509	44954

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.31 Da
• Isoelectric Point: 4.8519

>T31017 WP_001103944.1 NZ_AP014942:847928-848248 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKKLKITE

Nucleotide

• Length: 321 bp

>T31017 NZ_AP014942:847928-848248 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT31017 WP_001058492.1 NZ_AP014942:847716-847925 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT31017 NZ_AP014942:847716-847925 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q8VLW9

Antitoxin

• AlphaFold DB: X5IA75