Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 876835..877312 Replicon chromosome
Accession NZ_AP014921
Organism Staphylococcus aureus strain JH4899

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag JSA_RS04425 Protein ID WP_000052078.1
Coordinates 876835..877023 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JSA_RS04430 Protein ID WP_001059690.1
Coordinates 877052..877312 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSA_RS04395 872875..873345 + 471 WP_000824472.1 hypothetical protein -
JSA_RS04400 873686..874372 + 687 WP_001548082.1 thermonuclease family protein -
JSA_RS04405 874729..874929 + 201 WP_001059082.1 cold-shock protein -
JSA_RS04410 875426..875644 - 219 WP_000005886.1 hypothetical protein -
JSA_RS04415 875706..875990 - 285 WP_001004395.1 hypothetical protein -
JSA_RS04420 876078..876647 - 570 WP_001106654.1 hypothetical protein -
JSA_RS04425 876835..877023 - 189 WP_000052078.1 hypothetical protein Toxin
JSA_RS04430 877052..877312 - 261 WP_001059690.1 hypothetical protein Antitoxin
JSA_RS04435 877653..877856 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JSA_RS04440 877853..878089 - 237 WP_000368687.1 hypothetical protein -
JSA_RS04445 878314..878895 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
JSA_RS04450 878968..879585 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
JSA_RS04455 879740..880234 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JSA_RS04460 880633..881055 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JSA_RS04465 881203..881919 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - tsst-1 / sec / sell / vWbp 846038..887798 41760


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T31000 WP_000052078.1 NZ_AP014921:c877023-876835 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T31000 NZ_AP014921:c877023-876835 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT31000 WP_001059690.1 NZ_AP014921:c877312-877052 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT31000 NZ_AP014921:c877312-877052 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References