Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 389073..389584 Replicon chromosome
Accession NZ_AP014921
Organism Staphylococcus aureus strain JH4899

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag JSA_RS01850 Protein ID WP_031904328.1
Coordinates 389285..389584 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag JSA_RS01845 Protein ID WP_001060744.1
Coordinates 389073..389282 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSA_RS01800 384094..384924 - 831 Protein_337 KilA-N domain-containing protein -
JSA_RS01810 385407..386624 - 1218 WP_000270122.1 site-specific integrase -
JSA_RS01820 386918..387439 - 522 WP_001101554.1 hypothetical protein -
JSA_RS01825 387565..388260 - 696 WP_000700230.1 helix-turn-helix domain-containing protein -
JSA_RS01830 388405..388617 + 213 WP_000608987.1 hypothetical protein -
JSA_RS01835 388650..388922 + 273 WP_000867969.1 hypothetical protein -
JSA_RS01840 388934..389080 + 147 WP_000784888.1 hypothetical protein -
JSA_RS01845 389073..389282 + 210 WP_001060744.1 hypothetical protein Antitoxin
JSA_RS01850 389285..389584 + 300 WP_031904328.1 DUF1474 family protein Toxin
JSA_RS01855 389659..391272 + 1614 WP_033854769.1 hypothetical protein -
JSA_RS01860 391443..392246 + 804 WP_000148371.1 bifunctional DNA primase/polymerase -
JSA_RS01865 392233..392505 + 273 WP_001149387.1 hypothetical protein -
JSA_RS01870 392507..393156 + 650 Protein_349 pathogenicity island protein -
JSA_RS01875 393495..393836 + 342 WP_001161659.1 hypothetical protein -
JSA_RS01880 393848..394435 + 588 Protein_351 pathogenicity island protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 379052..404846 25794


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11680.15 Da        Isoelectric Point: 4.4740

>T30999 WP_031904328.1 NZ_AP014921:389285-389584 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSDVSLATESDDA

Download         Length: 300 bp

>T30999 NZ_AP014921:389285-389584 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8286.37 Da        Isoelectric Point: 4.4976

>AT30999 WP_001060744.1 NZ_AP014921:389073-389282 [Staphylococcus aureus]
MNNKQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT30999 NZ_AP014921:389073-389282 [Staphylococcus aureus]
ATGAATAATAAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References