Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1790016..1791711 Replicon chromosome
Accession NZ_AP014862
Organism Pseudomonas furukawaii strain KF707

Toxin (Protein)


Gene name doc Uniprot ID L8MJB4
Locus tag KF707C_RS08390 Protein ID WP_003452766.1
Coordinates 1790016..1790891 (+) Length 292 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag KF707C_RS08395 Protein ID WP_003452765.1
Coordinates 1790878..1791711 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF707C_RS08365 1786024..1786875 + 852 WP_081608092.1 ABC transporter ATP-binding protein -
KF707C_RS08370 1786913..1787908 + 996 WP_003452777.1 ABC transporter substrate-binding protein -
KF707C_RS08375 1787918..1788694 + 777 WP_003452773.1 ABC transporter permease -
KF707C_RS08380 1788700..1789461 + 762 WP_085986665.1 SDR family oxidoreductase -
KF707C_RS08385 1789477..1790007 + 531 WP_003452768.1 cupin domain-containing protein -
KF707C_RS08390 1790016..1790891 + 876 WP_003452766.1 alpha/beta hydrolase Toxin
KF707C_RS08395 1790878..1791711 + 834 WP_003452765.1 IclR family transcriptional regulator Antitoxin
KF707C_RS08400 1791698..1792495 + 798 WP_003452763.1 SDR family oxidoreductase -
KF707C_RS08405 1792488..1794170 + 1683 WP_003452760.1 thiamine pyrophosphate-binding protein -
KF707C_RS08410 1794181..1794984 + 804 WP_003452759.1 aspartate dehydrogenase -
KF707C_RS08415 1794995..1796479 + 1485 WP_003452757.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, C-terminal

(130-253)


Sequences

Toxin        


Download         Length: 292 a.a.        Molecular weight: 30818.33 Da        Isoelectric Point: 7.8794

>T30984 WP_003452766.1 NZ_AP014862:1790016-1790891 [Pseudomonas furukawaii]
MNMAQTRIPTPRLQQCFPERLVTVADGARVAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAEGNRVIAWDAPGYGLSTP
LPQARPKAVDYAARLEALLVALGVERCLLVGHSLGALMATAYAAGQGAQRVARLVLISPARGYGAEALRETGLRVRQQRL
DNLERLGIDGMASERTSRLLGRNPSEDALAWVRWNMARLNPAGYRQAVELLCGDDLLGNGRPAMPCEVHCGEDDAITSPE
ACGAIARGLDAPFSLIPAAGHASPIEQPDVVAGRIGHAQRLTLEGSAHGKA

Download         Length: 876 bp

>T30984 NZ_AP014862:1790016-1790891 [Pseudomonas furukawaii]
ATGAACATGGCGCAGACCCGCATCCCCACGCCGCGCTTGCAGCAGTGCTTCCCGGAGCGCCTGGTGACCGTCGCCGACGG
TGCCCGGGTGGCCATCCGCGAGTGCGGCCAGGGCCCGGTGGTGGTGCTCCTGCACGGTATCGGCTCCGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGAGGGCAACCGCGTGATCGCCTGGGACGCCCCCGGCTACGGCCTGTCCACGCCG
CTGCCGCAGGCAAGACCGAAAGCGGTCGACTACGCCGCCCGGCTGGAGGCGCTGCTGGTGGCCCTGGGCGTCGAGCGTTG
CCTGCTGGTGGGGCACTCCCTGGGCGCGCTGATGGCCACCGCCTACGCCGCAGGCCAGGGCGCCCAGCGCGTCGCCCGCC
TGGTGCTGATCAGCCCGGCGCGAGGCTACGGCGCCGAGGCCCTGCGGGAAACCGGGCTGCGGGTGCGCCAGCAGCGCCTG
GACAACCTCGAGCGGCTGGGCATCGACGGCATGGCCAGCGAGCGCACCAGCCGGCTGCTGGGGCGCAACCCCAGCGAGGA
CGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTGAACCCGGCCGGCTACCGCCAGGCGGTGGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGCCGGCCGGCGATGCCCTGCGAGGTGCATTGCGGCGAGGACGACGCCATCACCTCGCCGGAG
GCCTGCGGCGCCATCGCCCGGGGGCTGGACGCTCCCTTCTCGCTGATCCCCGCAGCCGGCCACGCCAGCCCCATCGAACA
ACCCGACGTGGTCGCAGGACGCATTGGTCACGCGCAACGCCTCACTCTTGAAGGATCCGCCCATGGAAAAGCCTGA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30918.42 Da        Isoelectric Point: 6.6960

>AT30984 WP_003452765.1 NZ_AP014862:1790878-1791711 [Pseudomonas furukawaii]
MEKPDDQQDKYIVPGLERGLLLLCEFSRKNRTLTAPELARRLKLPRSTIFRLLTTLETMGFVNRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNQLCDEIRYPCNLVVRDGRSIVYVAKVSPSTLLTSTVNVGTRLPAHATVLGRILLQDLSLSELR
ELYPEEHLESFSPNTPKTVLELFDLVQSDRLRGFVQGEGFFESTISTVAAPVRDHSGRVVAAMGATIPSAHIDPSRIDGL
VSAVRHSADELSHLLNYTPDGHDKVTSIFRSKQHEPV

Download         Length: 834 bp

>AT30984 NZ_AP014862:1790878-1791711 [Pseudomonas furukawaii]
ATGGAAAAGCCTGACGATCAACAAGACAAGTACATAGTGCCCGGCCTGGAGCGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGAACCGCACCCTGACCGCCCCCGAGCTGGCCCGGCGCCTGAAGCTGCCGCGCTCGACGATCTTCCGGCTGCTGA
CGACGCTGGAAACCATGGGCTTCGTCAATCGCAACGGCAACGAGTACCGCCTGGGCATGGCCGTGCTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAACTCACCGAACTGGGCCAGCCGCTGCTGAACCAGCTCTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTCCGCGATGGCCGTTCCATCGTCTACGTGGCCAAGGTCTCGCCCTCGACCCTGCTCACCAGCACGGTCA
ACGTCGGCACCCGCCTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGTCCCTCTCCGAGCTGCGC
GAGCTGTACCCGGAAGAGCACCTGGAAAGCTTCTCGCCGAACACCCCGAAGACCGTGCTGGAGCTGTTCGACCTGGTGCA
GAGCGACCGCCTGCGCGGATTCGTCCAGGGCGAGGGCTTCTTCGAGTCGACCATCTCCACGGTCGCCGCGCCGGTGCGCG
ACCACAGCGGCCGGGTGGTGGCCGCCATGGGCGCCACCATTCCCTCGGCGCACATCGATCCGTCCCGCATCGATGGCCTG
GTGAGCGCCGTGCGCCACAGCGCCGATGAGCTGTCCCACCTGCTGAACTACACCCCGGACGGCCACGACAAGGTGACCTC
CATCTTCCGGAGCAAGCAGCATGAGCCTGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L8MJB4

Antitoxin

Source ID Structure

References