Detailed information of TA system TA030976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3715008..3715620
• Replicon: chromosome
• Accession: NZ_AP014857
• Organism: Escherichia albertii strain EC06-170

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: U9YXE2
• Locus tag: AST80_RS18180
• Protein ID: WP_000833473.1
• Coordinates: 3715435..3715620 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AST80_RS18175
• Protein ID: WP_059235556.1
• Coordinates: 3715008..3715418 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AST80_RS18160	3710520..3711335	-	816	WP_059242247.1	AraC family transcriptional regulator	-
AST80_RS18165	3711561..3712961	+	1401	WP_025238099.1	MFS transporter	-
AST80_RS18170	3712972..3714936	+	1965	WP_060877502.1	glycoside hydrolase family 127 protein	-
AST80_RS18175	3715008..3715418	-	411	WP_059235556.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AST80_RS18180	3715435..3715620	-	186	WP_000833473.1	type II toxin-antitoxin system HicA family toxin	Toxin
AST80_RS18190	3716095..3717174	+	1080	WP_171841104.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
AST80_RS18195	3717215..3718753	-	1539	WP_002460288.1	aldehyde dehydrogenase AldB	-
AST80_RS18200	3718861..3720156	-	1296	WP_059235552.1	Fic family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6800.89 Da
• Isoelectric Point: 11.7053

>T30976 WP_000833473.1 NZ_AP014857:c3715620-3715435 [Escherichia albertii]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Nucleotide

• Length: 186 bp

>T30976 NZ_AP014857:c3715620-3715435 [Escherichia albertii]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15193.10 Da
• Isoelectric Point: 4.5486

>AT30976 WP_059235556.1 NZ_AP014857:c3715418-3715008 [Escherichia albertii]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQVEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Nucleotide

• Length: 411 bp

>AT30976 NZ_AP014857:c3715418-3715008 [Escherichia albertii]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGGTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Structures

Toxin

• AlphaFold DB: U9YXE2