Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2976493..2977144 Replicon chromosome
Accession NZ_AP014857
Organism Escherichia albertii strain EC06-170

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag AST80_RS14475 Protein ID WP_000244763.1
Coordinates 2976493..2976897 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag AST80_RS14480 Protein ID WP_000354046.1
Coordinates 2976878..2977144 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST80_RS14455 2972451..2974184 - 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -
AST80_RS14460 2974190..2974900 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AST80_RS14465 2974925..2975821 - 897 WP_059228147.1 site-specific tyrosine recombinase XerD -
AST80_RS14470 2975933..2976454 + 522 WP_059235395.1 flavodoxin FldB -
AST80_RS14475 2976493..2976897 - 405 WP_000244763.1 protein YgfX Toxin
AST80_RS14480 2976878..2977144 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
AST80_RS24770 2977134..2977364 - 231 WP_000181267.1 hypothetical protein -
AST80_RS14490 2977396..2978376 + 981 WP_059235393.1 tRNA-modifying protein YgfZ -
AST80_RS14495 2978817..2979476 - 660 WP_000250281.1 hemolysin III family protein -
AST80_RS14500 2979644..2979955 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
AST80_RS14505 2980000..2981433 + 1434 WP_059235410.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T30970 WP_000244763.1 NZ_AP014857:c2976897-2976493 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T30970 NZ_AP014857:c2976897-2976493 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT30970 WP_000354046.1 NZ_AP014857:c2977144-2976878 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT30970 NZ_AP014857:c2977144-2976878 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References