Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1564551..1565155 Replicon chromosome
Accession NZ_AP014857
Organism Escherichia albertii strain EC06-170

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag AST80_RS07545 Protein ID WP_000638401.1
Coordinates 1564551..1564937 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag AST80_RS07550 Protein ID WP_001195490.1
Coordinates 1564934..1565155 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST80_RS07545 1564551..1564937 - 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AST80_RS07550 1564934..1565155 - 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AST80_RS07555 1565584..1566342 + 759 WP_059236621.1 trans-aconitate 2-methyltransferase -
AST80_RS07560 1566346..1567260 - 915 WP_024164792.1 bestrophin family protein -
AST80_RS07570 1567465..1568916 - 1452 WP_000854601.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T30959 WP_000638401.1 NZ_AP014857:c1564937-1564551 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

>T30959 NZ_AP014857:c1564937-1564551 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT30959 WP_001195490.1 NZ_AP014857:c1565155-1564934 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp

>AT30959 NZ_AP014857:c1565155-1564934 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References