Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3050149..3050927 Replicon chromosome
Accession NZ_AP014856
Organism Escherichia albertii strain CB9786

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag AST72_RS15565 Protein ID WP_095576018.1
Coordinates 3050149..3050637 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag AST72_RS15570 Protein ID WP_095576019.1
Coordinates 3050634..3050927 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST72_RS15555 3049054..3049305 + 252 WP_095576016.1 hypothetical protein -
AST72_RS15560 3049517..3049969 + 453 WP_095576017.1 hypothetical protein -
AST72_RS15565 3050149..3050637 - 489 WP_095576018.1 GNAT family N-acetyltransferase Toxin
AST72_RS15570 3050634..3050927 - 294 WP_095576019.1 DUF1778 domain-containing protein Antitoxin
AST72_RS15575 3051156..3052202 + 1047 WP_095576020.1 DDE-type integrase/transposase/recombinase -
AST72_RS15580 3052478..3053356 - 879 WP_044712664.1 hypothetical protein -
AST72_RS15585 3053353..3054591 - 1239 WP_095576021.1 hypothetical protein -
AST72_RS15590 3054591..3055214 - 624 WP_000889448.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3051156..3052202 1046


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(74-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17654.52 Da        Isoelectric Point: 8.5163

>T30949 WP_095576018.1 NZ_AP014856:c3050637-3050149 [Escherichia albertii]
MISAPEPLHAGHVLTSFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCDNNSKVRAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGIGRALMRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPIDPMMLMVTLGDLV
HA

Download         Length: 489 bp

>T30949 NZ_AP014856:c3050637-3050149 [Escherichia albertii]
ATGATCTCCGCCCCTGAGCCTCTCCACGCCGGGCATGTTTTGACTTCATTTTGCTGCGGCGTGGATTCTATGGATAACTG
GCTGAAGCAGCGGGCGATGAAAAATCAGGTTACAGGTGCATCGCGTACCTTTGTTTGCTGTGACAACAATTCTAAGGTAC
GGGCATATTACTCGCTGGCGTCCAGCGCAGTGACGACAAATACCGCTCCCGGTCGCTTTCGCCGCAATATGCCTGACCCG
ATCCCGGTTGTGGTGTTGGGCCGTCTGGCGGTGGATAAATCGTTGCACGGGCAGGGCATCGGGCGGGCGCTGATGCGAGA
TGCCGGGCTACGGGTGATTCAGGTGGCGGAGACTATTGGCATTCGTGGAATGCTGGTTCACGCGTTGTCTGATGAAGCGC
GGGAGTTTTATTTGCGGGTGGGGTTTGAGCCGTCACCGATTGACCCGATGATGCTGATGGTGACGTTGGGGGATTTAGTT
CATGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10782.41 Da        Isoelectric Point: 10.5480

>AT30949 WP_095576019.1 NZ_AP014856:c3050927-3050634 [Escherichia albertii]
MPAANSLSIKRETLNLRIKPAERALIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMTDPDAYQAFLARLDQAPAPN
AALRKTMQTPAPWEQNK

Download         Length: 294 bp

>AT30949 NZ_AP014856:c3050927-3050634 [Escherichia albertii]
ATGCCAGCCGCAAACAGCCTGTCTATCAAGCGTGAAACGCTAAACCTGCGTATCAAACCAGCCGAGCGTGCTCTTATCGA
TCGTGCGGCGAAAGCCAGAGGAAAAAACCGCACGGATTTCGTGCTGGAAGCCGCTCGTGCTGCCGCAGAGGAAGCGCTGA
TAGAGCAGCGTATTATTATGACCGATCCCGATGCGTATCAGGCATTTCTCGCCCGTCTCGATCAGGCTCCTGCGCCAAAC
GCTGCGCTGCGTAAAACCATGCAGACACCTGCGCCGTGGGAGCAGAATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References