Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 470150..470768 Replicon chromosome
Accession NZ_AP014856
Organism Escherichia albertii strain CB9786

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag AST72_RS02415 Protein ID WP_001280991.1
Coordinates 470150..470368 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag AST72_RS02420 Protein ID WP_000344798.1
Coordinates 470394..470768 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST72_RS02380 465439..466011 + 573 WP_000779847.1 YbaY family lipoprotein -
AST72_RS02385 466041..466352 - 312 WP_000409915.1 MGMT family protein -
AST72_RS02395 466733..467086 + 354 WP_095575538.1 DUF1428 family protein -
AST72_RS02400 467124..468674 - 1551 WP_001260378.1 EAL domain-containing protein -
AST72_RS02405 468838..469308 - 471 WP_000136188.1 YlaC family protein -
AST72_RS02410 469416..469973 - 558 WP_095575539.1 maltose O-acetyltransferase -
AST72_RS02415 470150..470368 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
AST72_RS02420 470394..470768 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
AST72_RS02425 471323..474472 - 3150 WP_001132500.1 multidrug efflux RND transporter permease subunit -
AST72_RS02430 474495..475688 - 1194 WP_095575540.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T30937 WP_001280991.1 NZ_AP014856:c470368-470150 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T30937 NZ_AP014856:c470368-470150 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGCTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT30937 WP_000344798.1 NZ_AP014856:c470768-470394 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT30937 NZ_AP014856:c470768-470394 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACTAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References