Detailed information of TA system TA030932

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3619249..3619861
• Replicon: chromosome
• Accession: NZ_AP014855
• Organism: Escherichia albertii strain NIAH_Bird_3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: U9YXE2
• Locus tag: AST93_RS17980
• Protein ID: WP_000833473.1
• Coordinates: 3619676..3619861 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AST93_RS17975
• Protein ID: WP_095574350.1
• Coordinates: 3619249..3619659 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AST93_RS17960	3614761..3615576	-	816	WP_095574347.1	AraC family transcriptional regulator	-
AST93_RS17965	3615802..3617202	+	1401	WP_095574348.1	MFS transporter	-
AST93_RS17970	3617213..3619177	+	1965	WP_095574349.1	glycoside hydrolase family 127 protein	-
AST93_RS17975	3619249..3619659	-	411	WP_095574350.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AST93_RS17980	3619676..3619861	-	186	WP_000833473.1	type II toxin-antitoxin system HicA family toxin	Toxin
AST93_RS17990	3620336..3621415	+	1080	WP_172843676.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
AST93_RS17995	3621456..3622994	-	1539	WP_002460288.1	aldehyde dehydrogenase AldB	-
AST93_RS18000	3623102..3624397	-	1296	WP_059268237.1	Fic family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6800.89 Da
• Isoelectric Point: 11.7053

>T30932 WP_000833473.1 NZ_AP014855:c3619861-3619676 [Escherichia albertii]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Nucleotide

• Length: 186 bp

>T30932 NZ_AP014855:c3619861-3619676 [Escherichia albertii]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15231.11 Da
• Isoelectric Point: 4.5486

>AT30932 WP_095574350.1 NZ_AP014855:c3619659-3619249 [Escherichia albertii]
MFYPAYIHSDPDGSASGFFPDVSGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Nucleotide

• Length: 411 bp

>AT30932 NZ_AP014855:c3619659-3619249 [Escherichia albertii]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTTCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Structures

Toxin

• AlphaFold DB: U9YXE2