Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2873125..2873776 Replicon chromosome
Accession NZ_AP014855
Organism Escherichia albertii strain NIAH_Bird_3

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag AST93_RS14130 Protein ID WP_000244763.1
Coordinates 2873125..2873529 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag AST93_RS14135 Protein ID WP_000354046.1
Coordinates 2873510..2873776 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST93_RS14110 2869083..2870816 - 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -
AST93_RS14115 2870822..2871532 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AST93_RS14120 2871557..2872453 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
AST93_RS14125 2872565..2873086 + 522 WP_059221135.1 flavodoxin FldB -
AST93_RS14130 2873125..2873529 - 405 WP_000244763.1 protein YgfX Toxin
AST93_RS14135 2873510..2873776 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
AST93_RS22800 2873766..2873996 - 231 WP_000181267.1 hypothetical protein -
AST93_RS14140 2874028..2875008 + 981 WP_059221136.1 tRNA-modifying protein YgfZ -
AST93_RS14145 2875449..2876108 - 660 WP_000250281.1 hemolysin III family protein -
AST93_RS14150 2876276..2876587 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
AST93_RS14155 2876632..2878065 + 1434 WP_024164724.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T30927 WP_000244763.1 NZ_AP014855:c2873529-2873125 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T30927 NZ_AP014855:c2873529-2873125 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT30927 WP_000354046.1 NZ_AP014855:c2873776-2873510 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT30927 NZ_AP014855:c2873776-2873510 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References