Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 446573..447191 Replicon chromosome
Accession NZ_AP014855
Organism Escherichia albertii strain NIAH_Bird_3

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag AST93_RS02125 Protein ID WP_001280991.1
Coordinates 446573..446791 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag AST93_RS02130 Protein ID WP_000344798.1
Coordinates 446817..447191 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AST93_RS02090 441862..442434 + 573 WP_000779847.1 YbaY family lipoprotein -
AST93_RS02095 442464..442775 - 312 WP_172843666.1 MGMT family protein -
AST93_RS02105 443156..443509 + 354 WP_000878151.1 DUF1428 family protein -
AST93_RS02110 443547..445097 - 1551 WP_001260378.1 EAL domain-containing protein -
AST93_RS02115 445261..445731 - 471 WP_000136188.1 YlaC family protein -
AST93_RS02120 445839..446396 - 558 WP_059221620.1 maltose O-acetyltransferase -
AST93_RS02125 446573..446791 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
AST93_RS02130 446817..447191 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
AST93_RS02135 447746..450895 - 3150 WP_001132500.1 multidrug efflux RND transporter permease subunit -
AST93_RS02140 450918..452111 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T30913 WP_001280991.1 NZ_AP014855:c446791-446573 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T30913 NZ_AP014855:c446791-446573 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGCTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT30913 WP_000344798.1 NZ_AP014855:c447191-446817 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT30913 NZ_AP014855:c447191-446817 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACTAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References