Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143570..144075 Replicon chromosome
Accession NZ_AP014839
Organism Pseudomonas aeruginosa strain 8380

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PA8380_RS00640 Protein ID WP_003083773.1
Coordinates 143570..143851 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PA8380_RS00645 Protein ID WP_003083775.1
Coordinates 143848..144075 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA8380_RS00615 138821..140170 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
PA8380_RS00620 140219..140905 + 687 WP_003083762.1 FadR family transcriptional regulator -
PA8380_RS00625 141006..141740 + 735 WP_003117208.1 GntR family transcriptional regulator -
PA8380_RS00630 141944..142330 + 387 WP_014602345.1 aegerolysin family protein -
PA8380_RS00635 142362..143270 - 909 WP_031630492.1 LysR family transcriptional regulator -
PA8380_RS00640 143570..143851 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PA8380_RS00645 143848..144075 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PA8380_RS00650 144251..144871 - 621 WP_023088714.1 hypothetical protein -
PA8380_RS00655 144972..145472 + 501 WP_003101228.1 LEA type 2 family protein -
PA8380_RS00660 145545..145886 + 342 WP_003101229.1 alkylphosphonate utilization protein -
PA8380_RS00665 145968..147395 - 1428 WP_031630494.1 GABA permease -
PA8380_RS00670 147564..149057 - 1494 WP_031630496.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T30899 WP_003083773.1 NZ_AP014839:c143851-143570 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T30899 NZ_AP014839:c143851-143570 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGTACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT30899 WP_003083775.1 NZ_AP014839:c144075-143848 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT30899 NZ_AP014839:c144075-143848 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTAGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References