Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3152378..3153353 Replicon chromosome
Accession NZ_AP014833
Organism Bacillus anthracis strain Shikan-NIID

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag BASH2_RS17675 Protein ID WP_002036394.1
Coordinates 3152616..3153353 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BASH2_RS17670 Protein ID WP_000588712.1
Coordinates 3152378..3152503 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BASH2_RS17630 3148132..3148602 + 471 WP_000670597.1 DUF5065 family protein -
BASH2_RS17640 3149166..3150635 - 1470 WP_000287522.1 beta-Ala-His dipeptidase -
BASH2_RS31095 3150779..3150955 - 177 WP_000808045.1 hypothetical protein -
BASH2_RS17655 3151294..3151530 + 237 WP_001021689.1 hypothetical protein -
BASH2_RS17660 3151807..3152088 + 282 WP_001041555.1 hypothetical protein -
BASH2_RS31100 3152125..3152301 - 177 WP_000852614.1 hypothetical protein -
BASH2_RS17670 3152378..3152503 - 126 WP_000588712.1 hypothetical protein Antitoxin
BASH2_RS17675 3152616..3153353 - 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BASH2_RS17685 3153542..3154279 - 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BASH2_RS17690 3154447..3154929 - 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
BASH2_RS17695 3155036..3156721 + 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
BASH2_RS17700 3156843..3157625 - 783 WP_000381787.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T30897 WP_002036394.1 NZ_AP014833:c3153353-3152616 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T30897 NZ_AP014833:c3153353-3152616 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT30897 WP_000588712.1 NZ_AP014833:c3152503-3152378 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT30897 NZ_AP014833:c3152503-3152378 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References