Detailed information of TA system TA030897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 3152378..3153353
• Replicon: chromosome
• Accession: NZ_AP014833
• Organism: Bacillus anthracis strain Shikan-NIID

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: A0A2R2IKP2
• Locus tag: BASH2_RS17675
• Protein ID: WP_002036394.1
• Coordinates: 3152616..3153353 (-)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: R8HWP4
• Locus tag: BASH2_RS17670
• Protein ID: WP_000588712.1
• Coordinates: 3152378..3152503 (-)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BASH2_RS17630	3148132..3148602	+	471	WP_000670597.1	DUF5065 family protein	-
BASH2_RS17640	3149166..3150635	-	1470	WP_000287522.1	beta-Ala-His dipeptidase	-
BASH2_RS31095	3150779..3150955	-	177	WP_000808045.1	hypothetical protein	-
BASH2_RS17655	3151294..3151530	+	237	WP_001021689.1	hypothetical protein	-
BASH2_RS17660	3151807..3152088	+	282	WP_001041555.1	hypothetical protein	-
BASH2_RS31100	3152125..3152301	-	177	WP_000852614.1	hypothetical protein	-
BASH2_RS17670	3152378..3152503	-	126	WP_000588712.1	hypothetical protein	Antitoxin
BASH2_RS17675	3152616..3153353	-	738	WP_002036394.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
BASH2_RS17685	3153542..3154279	-	738	WP_000594139.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
BASH2_RS17690	3154447..3154929	-	483	WP_000191911.1	MarR family winged helix-turn-helix transcriptional regulator	-
BASH2_RS17695	3155036..3156721	+	1686	WP_009879073.1	alpha-keto acid decarboxylase family protein	-
BASH2_RS17700	3156843..3157625	-	783	WP_000381787.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28373.03 Da
• Isoelectric Point: 8.2705

>T30897 WP_002036394.1 NZ_AP014833:c3153353-3152616 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T30897 NZ_AP014833:c3153353-3152616 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.34 Da
• Isoelectric Point: 3.9150

>AT30897 WP_000588712.1 NZ_AP014833:c3152503-3152378 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Nucleotide

• Length: 126 bp

>AT30897 NZ_AP014833:c3152503-3152378 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Toxin

• AlphaFold DB: A0A2R2IKP2

Antitoxin

• AlphaFold DB: A0A366GQT1