Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1787896..1788413 Replicon chromosome
Accession NZ_AP014821
Organism Geminocystis sp. NIES-3709

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6AR06
Locus tag GM3709_RS07675 Protein ID WP_066118013.1
Coordinates 1788159..1788413 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0D6APP7
Locus tag GM3709_RS07670 Protein ID WP_066118011.1
Coordinates 1787896..1788153 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM3709_RS07650 1784745..1784963 + 219 WP_066118000.1 NAD(P)H-quinone oxidoreductase subunit O -
GM3709_RS07655 1784967..1785944 + 978 WP_066118002.1 malate dehydrogenase -
GM3709_RS07660 1786113..1786649 + 537 WP_066118004.1 dCMP deaminase family protein -
GM3709_RS07665 1786734..1787774 + 1041 WP_066118006.1 class 1 fructose-bisphosphatase -
GM3709_RS07670 1787896..1788153 + 258 WP_066118011.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GM3709_RS07675 1788159..1788413 + 255 WP_066118013.1 Txe/YoeB family addiction module toxin Toxin
GM3709_RS07680 1788482..1789741 + 1260 WP_066118015.1 lipid-A-disaccharide synthase-related protein -
GM3709_RS07685 1789749..1790570 + 822 WP_066118017.1 pentapeptide repeat-containing protein -
GM3709_RS07690 1790578..1791564 - 987 WP_066118020.1 serine hydrolase -
GM3709_RS07695 1791832..1792731 - 900 WP_082712962.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10403.87 Da        Isoelectric Point: 7.2734

>T30894 WP_066118013.1 NZ_AP014821:1788159-1788413 [Geminocystis sp. NIES-3709]
MKISFLEDGWHDYLYWQNQDKKTLKRINQIIKDIERNPYDGIGKSEPLKFDFSGLWSRRINQEHRLIYQILDDEIIIIQC
RYHY

Download         Length: 255 bp

>T30894 NZ_AP014821:1788159-1788413 [Geminocystis sp. NIES-3709]
ATGAAAATTTCCTTTTTGGAAGACGGTTGGCATGATTATTTGTATTGGCAAAATCAAGATAAAAAAACTTTAAAAAGAAT
TAATCAAATCATCAAAGATATAGAAAGGAATCCTTATGATGGTATTGGCAAATCTGAACCCTTAAAATTTGATTTTAGTG
GATTATGGTCAAGACGTATTAATCAAGAACATCGCTTAATTTATCAGATTTTAGACGATGAAATTATTATTATTCAATGT
CGTTATCATTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9917.29 Da        Isoelectric Point: 5.6165

>AT30894 WP_066118011.1 NZ_AP014821:1787896-1788153 [Geminocystis sp. NIES-3709]
MDAITYTQARKNFTHVMNQVCENHAPIIITRQSEKPVVMMSLEDYSSLEETLYLLRSPKNAQRLYKALGELKQGKYESHE
LIEDE

Download         Length: 258 bp

>AT30894 NZ_AP014821:1787896-1788153 [Geminocystis sp. NIES-3709]
ATGGATGCAATCACTTATACTCAAGCCCGAAAAAATTTTACCCATGTAATGAATCAGGTTTGCGAAAATCATGCCCCAAT
TATCATTACTCGTCAATCAGAAAAACCTGTTGTCATGATGTCTCTTGAAGATTATAGTTCTCTCGAAGAGACATTATATT
TATTAAGAAGTCCAAAAAATGCTCAACGACTTTACAAAGCATTAGGAGAATTAAAACAAGGAAAATACGAAAGCCATGAG
TTAATCGAAGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6AR06

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6APP7

References