Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2265535..2266149 Replicon chromosome
Accession NZ_AP014815
Organism Geminocystis sp. NIES-3708

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GM3708_RS10020 Protein ID WP_066346262.1
Coordinates 2265796..2266149 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GM3708_RS10015 Protein ID WP_066349405.1
Coordinates 2265535..2265765 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM3708_RS09990 2261951..2263174 - 1224 WP_071827608.1 AAA family ATPase -
GM3708_RS09995 2263267..2263905 - 639 WP_066346256.1 hypothetical protein -
GM3708_RS10000 2264204..2264626 - 423 WP_066346258.1 putative toxin-antitoxin system toxin component, PIN family -
GM3708_RS10005 2264604..2264834 - 231 WP_066346260.1 hypothetical protein -
GM3708_RS10010 2265139..2265363 + 225 WP_066346261.1 hypothetical protein -
GM3708_RS10015 2265535..2265765 + 231 WP_066349405.1 DUF2281 domain-containing protein Antitoxin
GM3708_RS10020 2265796..2266149 + 354 WP_066346262.1 type II toxin-antitoxin system VapC family toxin Toxin
GM3708_RS10025 2266287..2266508 + 222 WP_066346263.1 type II toxin-antitoxin system HicB family antitoxin -
GM3708_RS10030 2266530..2268584 - 2055 WP_066346266.1 WYL domain-containing protein -
GM3708_RS10035 2268597..2269496 - 900 WP_066346269.1 hypothetical protein -
GM3708_RS10040 2269525..2270637 - 1113 WP_066346271.1 reverse transcriptase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Domain of unknown function DUF2281

(6-74)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13719.14 Da        Isoelectric Point: 7.1648

>T30892 WP_066346262.1 NZ_AP014815:2265796-2266149 [Geminocystis sp. NIES-3708]
IWLSENDPNLPINLRQKIDSAEKVYLSIISLWEIAIKINIGKLSLKKSYQHIENELKLSDILLLPITFANTQRLCNLPLY
HRDPFDRMLIVQAMERELILVSKDTKFSAYPIEILRE

Download         Length: 354 bp

>T30892 NZ_AP014815:2265796-2266149 [Geminocystis sp. NIES-3708]
ATTTGGTTGTCAGAAAACGATCCTAATTTGCCAATTAATCTAAGACAAAAAATTGACTCCGCCGAAAAAGTTTATTTAAG
TATTATTAGCCTTTGGGAGATTGCCATTAAAATCAATATCGGGAAATTATCCCTTAAAAAAAGTTATCAACATATTGAAA
ATGAACTAAAATTATCGGACATTCTCTTATTACCAATTACTTTTGCTAACACTCAAAGACTATGCAATTTACCATTATAT
CATCGAGATCCTTTTGATAGAATGTTAATTGTTCAAGCAATGGAAAGAGAATTAATTTTAGTGAGTAAAGATACTAAATT
TTCTGCTTATCCCATTGAAATATTACGGGAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8955.93 Da        Isoelectric Point: 4.0179

>AT30892 WP_066349405.1 NZ_AP014815:2265535-2265765 [Geminocystis sp. NIES-3708]
INIETKILETLDKMPVSLQEELLHYAEYLQEKYSENNGNINTSNQKRRSGILEGTFVLPLPDDFDESLEDFEEYMR

Download         Length: 231 bp

>AT30892 NZ_AP014815:2265535-2265765 [Geminocystis sp. NIES-3708]
ATAAATATTGAAACTAAAATATTAGAAACTTTAGACAAAATGCCCGTATCTTTGCAAGAAGAATTATTGCATTATGCGGA
GTATCTTCAGGAAAAATATAGCGAAAATAATGGAAATATAAACACTTCTAATCAAAAACGTCGCTCAGGTATTTTAGAGG
GTACTTTTGTTTTACCCTTACCTGATGATTTTGATGAATCTTTAGAAGATTTTGAGGAATATATGAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References