Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 653513..653919 Replicon chromosome
Accession NZ_AP014815
Organism Geminocystis sp. NIES-3708

Toxin (Protein)


Gene name hicA Uniprot ID A0A0D6ABN1
Locus tag GM3708_RS02715 Protein ID WP_066343914.1
Coordinates 653513..653707 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0D6ACF5
Locus tag GM3708_RS02720 Protein ID WP_066343916.1
Coordinates 653704..653919 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM3708_RS02695 649247..650752 + 1506 WP_066343910.1 TonB family protein -
GM3708_RS02700 650886..651239 + 354 WP_144439268.1 PilZ domain-containing protein -
GM3708_RS02705 651337..652167 - 831 WP_066343912.1 prolipoprotein diacylglyceryl transferase -
GM3708_RS02710 652230..653471 + 1242 WP_066343913.1 NAD(P)/FAD-dependent oxidoreductase -
GM3708_RS02715 653513..653707 + 195 WP_066343914.1 type II toxin-antitoxin system HicA family toxin Toxin
GM3708_RS02720 653704..653919 + 216 WP_066343916.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GM3708_RS02725 653951..654856 + 906 WP_066343918.1 ABC transporter ATP-binding protein -
GM3708_RS02730 654853..656973 - 2121 WP_066343920.1 DNA helicase RecQ -
GM3708_RS02735 657230..657346 - 117 WP_066343921.1 cytochrome b6-f complex subunit PetG -
GM3708_RS02740 657598..657990 + 393 WP_066343922.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-62)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7423.85 Da        Isoelectric Point: 10.9041

>T30889 WP_066343914.1 NZ_AP014815:653513-653707 [Geminocystis sp. NIES-3708]
MKVKDVLKRLKKDGWYQVRMRGSHRFLAHLQKKGIVVVPGKLSNDIPIGTLNVIWKQAQLEDEI

Download         Length: 195 bp

>T30889 NZ_AP014815:653513-653707 [Geminocystis sp. NIES-3708]
ATGAAAGTTAAAGACGTGCTAAAACGATTAAAAAAAGATGGATGGTATCAAGTGAGAATGCGTGGGAGTCATCGATTTTT
AGCTCATCTTCAAAAAAAAGGTATTGTAGTAGTTCCGGGTAAACTAAGTAATGATATACCGATTGGAACATTAAACGTTA
TTTGGAAACAAGCACAATTAGAAGACGAAATATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7868.95 Da        Isoelectric Point: 3.8774

>AT30889 WP_066343916.1 NZ_AP014815:653704-653919 [Geminocystis sp. NIES-3708]
MKQYVVIYEKGETNWGAIVPDLPGCVSIGDTFEQVQENIKEAISVYLEVLVERGETIPQPQTQVGFVEIAA

Download         Length: 216 bp

>AT30889 NZ_AP014815:653704-653919 [Geminocystis sp. NIES-3708]
ATGAAACAATATGTAGTAATCTATGAAAAAGGAGAGACAAATTGGGGAGCGATTGTACCCGACTTACCCGGTTGTGTGAG
TATTGGGGATACTTTTGAACAAGTTCAAGAAAATATCAAAGAAGCCATCTCTGTTTACTTAGAAGTTTTGGTAGAAAGAG
GAGAAACAATCCCTCAACCTCAAACTCAAGTAGGATTTGTGGAAATAGCGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6ABN1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6ACF5

References