Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 15364..15988 Replicon plasmid Plasmid2 DNA
Accession NZ_AP014802
Organism Rhodovulum sulfidophilum

Toxin (Protein)


Gene name vapC Uniprot ID A0A0D6B8X4
Locus tag NHU_RS21110 Protein ID WP_060836698.1
Coordinates 15584..15988 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0D6B8X2
Locus tag NHU_RS21105 Protein ID WP_060836697.1
Coordinates 15364..15594 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHU_RS21085 11477..11983 - 507 WP_060836693.1 TRAP transporter small permease -
NHU_RS21090 12084..13241 - 1158 WP_060836694.1 TRAP transporter substrate-binding protein -
NHU_RS21095 13285..13509 - 225 WP_060836695.1 hypothetical protein -
NHU_RS21100 13623..14666 + 1044 WP_060836696.1 LacI family DNA-binding transcriptional regulator -
NHU_RS21105 15364..15594 + 231 WP_060836697.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NHU_RS21110 15584..15988 + 405 WP_060836698.1 PIN domain-containing protein Toxin
NHU_RS21115 16092..16763 + 672 WP_042465589.1 SDR family NAD(P)-dependent oxidoreductase -
NHU_RS21120 16777..17661 - 885 WP_060836699.1 DMT family transporter -
NHU_RS21125 17955..18575 + 621 WP_060836700.1 exopolysaccharide biosynthesis protein -
NHU_RS21130 19059..19682 + 624 WP_060836701.1 RNA ligase family protein -
NHU_RS21135 20243..20884 - 642 WP_060836702.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..106137 106137


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-39)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14548.58 Da        Isoelectric Point: 4.2953

>T30883 WP_060836698.1 NZ_AP014802:15584-15988 [Rhodovulum sulfidophilum]
MAADFFDTNVILYLLDDGPKADRAEALLAQGGTISVQVLNEALVNCLRKARISHDEAGEFLFGIRDLCETVELSVDTHDV
GRALAARYKLSVYDSMIVAAALLSGCTRLWSEDMQDGLTVEGRLKIVNPFADAA

Download         Length: 405 bp

>T30883 NZ_AP014802:15584-15988 [Rhodovulum sulfidophilum]
ATGGCCGCTGACTTCTTCGACACCAACGTCATCCTCTACCTGCTGGACGACGGGCCCAAGGCCGACCGGGCCGAGGCGCT
GCTGGCCCAGGGCGGCACGATCAGCGTCCAGGTGCTGAACGAGGCGCTGGTGAACTGCCTGCGCAAGGCCCGGATAAGCC
ATGACGAAGCGGGGGAATTCCTGTTCGGGATCCGCGATCTCTGCGAGACGGTCGAGCTGAGCGTCGACACCCATGATGTC
GGCCGCGCGCTGGCCGCCCGCTACAAGCTGTCGGTCTACGATTCGATGATCGTTGCCGCAGCTCTTCTCAGCGGCTGCAC
CAGGCTCTGGTCCGAGGACATGCAAGACGGCCTGACCGTCGAGGGGCGGCTGAAGATCGTCAACCCCTTCGCCGACGCCG
CCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8476.60 Da        Isoelectric Point: 11.8979

>AT30883 WP_060836697.1 NZ_AP014802:15364-15594 [Rhodovulum sulfidophilum]
MQIARWGNSLAVRLPADLVRTLGLREGDRIELEPSGEGRLAVSRHPRADEVLSGLRRFRGRLASEDRLSRDAANGR

Download         Length: 231 bp

>AT30883 NZ_AP014802:15364-15594 [Rhodovulum sulfidophilum]
ATGCAGATCGCCAGATGGGGAAATTCCCTTGCCGTCCGCCTGCCCGCGGATCTGGTCCGGACTCTCGGCCTGCGCGAGGG
CGACCGGATCGAGCTGGAGCCCTCGGGCGAGGGTCGGCTTGCAGTCAGCCGCCATCCCCGTGCCGATGAGGTGCTGTCGG
GGCTGCGCCGGTTCCGCGGCCGTCTGGCGTCCGAAGACCGGCTGAGCCGCGACGCGGCCAATGGCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6B8X4

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6B8X2

References