Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4228047..4228634 Replicon chromosome
Accession NZ_AP014800
Organism Rhodovulum sulfidophilum

Toxin (Protein)


Gene name PumA Uniprot ID A0A0D6B820
Locus tag NHU_RS19470 Protein ID WP_060836211.1
Coordinates 4228344..4228634 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0D6B893
Locus tag NHU_RS19465 Protein ID WP_060836210.1
Coordinates 4228047..4228334 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHU_RS19440 4223829..4224347 + 519 WP_082241756.1 hypothetical protein -
NHU_RS19445 4224347..4224820 + 474 WP_060836206.1 single-stranded DNA-binding protein -
NHU_RS19450 4224831..4225475 + 645 WP_060836207.1 hypothetical protein -
NHU_RS19455 4225486..4226136 + 651 WP_060836208.1 hypothetical protein -
NHU_RS19460 4226203..4227576 - 1374 WP_060836209.1 NAD-dependent succinate-semialdehyde dehydrogenase -
NHU_RS19465 4228047..4228334 - 288 WP_060836210.1 putative addiction module antidote protein Antitoxin
NHU_RS19470 4228344..4228634 - 291 WP_060836211.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHU_RS19475 4228820..4229029 + 210 WP_060836212.1 hypothetical protein -
NHU_RS19480 4229325..4229834 + 510 WP_060836213.1 terminase small subunit -
NHU_RS19485 4229864..4231186 + 1323 WP_060836602.1 phage terminase large subunit -
NHU_RS19490 4231186..4232550 + 1365 WP_060836214.1 DUF1073 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4207979..4247559 39580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10925.69 Da        Isoelectric Point: 10.0301

>T30882 WP_060836211.1 NZ_AP014800:c4228634-4228344 [Rhodovulum sulfidophilum]
MSYEIHQSAEFSKWLRKLKDRTAQARIAIRIARLEAGLMGDAKFFDGIGELRITYGPGYRVYFVQQGETIIILLCGGDKG
SQRRDIEKAKTMAKEL

Download         Length: 291 bp

>T30882 NZ_AP014800:c4228634-4228344 [Rhodovulum sulfidophilum]
ATGAGTTACGAAATTCACCAGTCCGCCGAGTTCTCGAAATGGCTTCGCAAGCTGAAAGACCGCACGGCGCAAGCCCGCAT
CGCGATCAGGATCGCCCGGCTCGAGGCTGGGCTGATGGGCGATGCCAAGTTCTTCGACGGCATCGGTGAACTTCGGATCA
CCTACGGCCCGGGATACCGCGTCTACTTCGTCCAGCAGGGCGAGACGATCATCATCCTGCTCTGCGGCGGCGACAAAGGC
TCCCAGCGCCGGGACATCGAAAAGGCCAAGACCATGGCCAAGGAACTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 9993.43 Da        Isoelectric Point: 5.6939

>AT30882 WP_060836210.1 NZ_AP014800:c4228334-4228047 [Rhodovulum sulfidophilum]
MPIETTRFDAAEYLDTPEAQAMLLSDAFETGDAAYIKHAIGIVARARGIKDTAEAAGVTREALHRALGEKGNPRLSTILG
VTKALGLTLKVEAAA

Download         Length: 288 bp

>AT30882 NZ_AP014800:c4228334-4228047 [Rhodovulum sulfidophilum]
ATGCCTATCGAAACTACCCGCTTCGACGCGGCCGAATATCTCGATACGCCGGAAGCGCAAGCCATGCTGCTTTCCGACGC
CTTCGAGACGGGTGACGCCGCCTACATCAAGCACGCCATCGGGATCGTCGCCAGGGCGCGCGGGATCAAGGACACGGCCG
AGGCCGCCGGGGTCACGCGGGAGGCGCTGCACCGCGCCTTGGGTGAGAAGGGAAACCCGAGGCTGTCTACCATCCTCGGC
GTGACGAAGGCGCTCGGGCTGACCTTGAAGGTCGAGGCGGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6B820

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6B893

References