Detailed information of TA system TA030880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4208999..4209648
• Replicon: chromosome
• Accession: NZ_AP014704
• Organism: Methylobacterium aquaticum strain MA-22A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: Maq22A_RS35195
• Protein ID: WP_082742616.1
• Coordinates: 4209439..4209648 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: Maq22A_RS19075
• Protein ID: WP_060849516.1
• Coordinates: 4208999..4209403 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Maq22A_RS19060	4205199..4206479	+	1281	WP_060848312.1	hydroxymethylglutaryl-CoA reductase, degradative	-
Maq22A_RS19065	4206740..4207969	+	1230	WP_060848313.1	ABC transporter substrate-binding protein	-
Maq22A_RS19070	4207966..4208859	+	894	WP_060848314.1	hydroxymethylglutaryl-CoA lyase	-
Maq22A_RS19075	4208999..4209403	-	405	WP_060849516.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Maq22A_RS35195	4209439..4209648	-	210	WP_082742616.1	type II toxin-antitoxin system HicA family toxin	Toxin
Maq22A_RS19080	4209875..4211458	-	1584	WP_091889140.1	galactarate dehydratase	-
Maq22A_RS19085	4211575..4212570	-	996	WP_060848316.1	DUF4892 domain-containing protein	-
Maq22A_RS19090	4212631..4214337	-	1707	WP_082742617.1	hybrid sensor histidine kinase/response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (11-67)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (8-126)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7744.84 Da
• Isoelectric Point: 10.7459

>T30880 WP_082742616.1 NZ_AP014704:c4209648-4209439 [Methylobacterium aquaticum]
MAPKQRSRKTRDVLSMLAKDGWFVARKGPGDHVQYKHPTKPGKVTVDGGASEIPTGTLHNIYRQAGWEW

Nucleotide

• Length: 210 bp

>T30880 NZ_AP014704:c4209648-4209439 [Methylobacterium aquaticum]
ATGGCTCCCAAACAGAGAAGCCGCAAAACCCGCGACGTGCTCTCGATGCTCGCGAAGGACGGATGGTTCGTCGCCCGCAA
GGGGCCCGGTGATCACGTTCAGTACAAGCACCCGACCAAGCCTGGAAAGGTTACGGTCGATGGCGGGGCGTCCGAGATCC
CGACTGGGACGCTTCACAACATCTACCGGCAAGCGGGATGGGAGTGGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14197.12 Da
• Isoelectric Point: 4.6364

>AT30880 WP_060849516.1 NZ_AP014704:c4209403-4208999 [Methylobacterium aquaticum]
MARVVMLVHEEEGVFGASFPDFPGATTVADDLDTLYRKAAEMLAFHVGGMAEDGDAIPTLRTLSELQQDPVFREDGKGAM
IGLVDVDLPGKAVRVNVSIEEGLLKRIDHAAAAAGESRSSFLARAARARLSTAA

Nucleotide

• Length: 405 bp

>AT30880 NZ_AP014704:c4209403-4208999 [Methylobacterium aquaticum]
ATGGCGCGCGTCGTCATGCTGGTTCACGAAGAAGAGGGAGTCTTCGGCGCCTCGTTCCCGGATTTTCCGGGTGCGACGAC
CGTCGCCGACGACCTCGACACGCTCTATCGCAAAGCGGCCGAGATGCTCGCCTTCCACGTCGGCGGCATGGCCGAGGACG
GAGACGCCATTCCGACTCTGCGCACCCTGAGCGAACTGCAGCAGGACCCGGTGTTCCGGGAAGACGGCAAAGGCGCCATG
ATCGGCCTCGTCGATGTCGATCTGCCCGGCAAGGCGGTGCGGGTGAACGTCTCCATCGAGGAGGGCCTCCTCAAGCGGAT
CGACCACGCGGCGGCGGCGGCCGGCGAGAGCCGGTCGAGTTTCCTCGCCCGGGCCGCTCGGGCGCGCCTGTCGACGGCAG
CATGA