Detailed information of TA system TA030879

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 4195842..4196433
• Replicon: chromosome
• Accession: NZ_AP014704
• Organism: Methylobacterium aquaticum strain MA-22A

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: Maq22A_RS35190
• Protein ID: WP_082742612.1
• Coordinates: 4196143..4196433 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: A0A0C6FJV7
• Locus tag: Maq22A_RS19020
• Protein ID: WP_060848305.1
• Coordinates: 4195842..4196138 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Maq22A_RS19005	4190882..4191841	-	960	WP_060849514.1	hypothetical protein	-
Maq22A_RS35185	4191860..4192087	-	228	Protein_3839	hypothetical protein	-
Maq22A_RS19010	4192854..4194224	+	1371	WP_060848303.1	globin-coupled sensor protein	-
Maq22A_RS19015	4194331..4195821	+	1491	WP_060848304.1	mannitol dehydrogenase family protein	-
Maq22A_RS19020	4195842..4196138	-	297	WP_060848305.1	putative addiction module antidote protein	Antitoxin
Maq22A_RS35190	4196143..4196433	-	291	WP_082742612.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Maq22A_RS19025	4196614..4197915	+	1302	WP_082742613.1	sugar ABC transporter substrate-binding protein	-
Maq22A_RS19030	4198316..4199215	+	900	WP_082742614.1	sugar ABC transporter permease	-
Maq22A_RS19035	4199217..4200035	+	819	WP_060848307.1	carbohydrate ABC transporter permease	-
Maq22A_RS19040	4200047..4201150	+	1104	WP_060848308.1	sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Uncharacterized protein HI1420 (6-91)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10872.52 Da
• Isoelectric Point: 10.8593

>T30879 WP_082742612.1 NZ_AP014704:c4196433-4196143 [Methylobacterium aquaticum]
MPSIRQTLVFRAWIAGLRDERARLRINTRIRRLSLGNPGDVKTVGDGVSELRIDYGPGYRVYFTQRGSEIVILLCGGDKR
TQDKDILAAKRLANQE

Nucleotide

• Length: 291 bp

>T30879 NZ_AP014704:c4196433-4196143 [Methylobacterium aquaticum]
ATGCCGTCGATCCGACAAACTCTCGTCTTCCGTGCGTGGATCGCCGGCCTTCGCGACGAGCGTGCTCGGTTGCGGATCAA
TACTCGTATCAGGCGCCTGTCGCTCGGAAATCCGGGTGACGTGAAAACCGTTGGAGACGGTGTCAGCGAGCTGCGGATCG
ACTACGGCCCGGGCTATCGAGTCTACTTCACGCAACGCGGATCGGAGATCGTGATCCTGCTTTGTGGAGGTGACAAGCGT
ACGCAAGACAAGGACATCCTCGCTGCGAAGCGACTCGCGAATCAGGAGTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10332.96 Da
• Isoelectric Point: 4.2412

>AT30879 WP_060848305.1 NZ_AP014704:c4196138-4195842 [Methylobacterium aquaticum]
MPLETVPWDIVDSLDTPERVALYLEAVLEEGDPALLAAALGDVARAQGMTQIAKETGLSRETLYRTLSDKGNPQLATLMA
VLKSLGLKLTVAPVTGAA

Nucleotide

• Length: 297 bp

>AT30879 NZ_AP014704:c4196138-4195842 [Methylobacterium aquaticum]
ATGCCTCTCGAGACCGTCCCATGGGACATTGTCGACAGCCTCGACACGCCGGAGCGCGTGGCCCTCTACCTGGAAGCCGT
CCTGGAGGAAGGGGATCCCGCACTTCTCGCCGCCGCCCTCGGCGACGTCGCCCGGGCGCAAGGCATGACCCAGATCGCCA
AGGAGACCGGCCTGTCGCGGGAAACCCTGTACCGGACCCTGTCCGACAAGGGGAACCCGCAACTCGCGACCCTGATGGCC
GTGCTCAAGTCCCTCGGACTGAAGCTGACCGTCGCGCCGGTGACCGGGGCGGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0C6FJV7