Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 2966880..2967538 Replicon chromosome
Accession NZ_AP014704
Organism Methylobacterium aquaticum strain MA-22A

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C6FCQ3
Locus tag Maq22A_RS13580 Protein ID WP_060847420.1
Coordinates 2966880..2967284 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Maq22A_RS13585 Protein ID WP_099053403.1
Coordinates 2967281..2967538 (-) Length 86 a.a.

Genomic Context


Maq22A_RS13560Maq22A_RS13570Maq22A_RS13575Maq22A_RS13590Maq22A_RS13595Maq22A_RS13600Maq22A_RS13565Maq22A_RS13580Maq22A_RS13585Maq22A_RS13605Maq22A_RS13610
Location: 2963143..2964231 (1089 bp)
Type: Others
Protein ID: WP_060849395.1
Location: 2965477..2966076 (600 bp)
Type: Others
Protein ID: WP_060847418.1
Location: 2966325..2966774 (450 bp)
Type: Others
Protein ID: WP_060847419.1
Location: 2967799..2968248 (450 bp)
Type: Others
Protein ID: WP_060847422.1
Location: 2968492..2970495 (2004 bp)
Type: Others
Protein ID: WP_060847423.1
Location: 2970513..2970929 (417 bp)
Type: Others
Protein ID: WP_060847424.1
Location: 2964351..2965280 (930 bp)
Type: Others
Protein ID: WP_060847417.1
Location: 2966880..2967284 (405 bp)
Type: Toxin
Protein ID: WP_060847420.1
Location: 2967281..2967538 (258 bp)
Type: Antitoxin
Protein ID: WP_099053403.1
Location: 2971258..2971680 (423 bp)
Type: Others
Protein ID: WP_060847425.1
Location: 2971677..2972336 (660 bp)
Type: Others
Protein ID: WP_060847426.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Maq22A_RS135602963143..2964231+1089WP_060849395.13,4-dihydroxy-2-butanone-4-phosphate synthase-
Maq22A_RS135652964351..2965280-930WP_060847417.1histone deacetylase family protein-
Maq22A_RS135702965477..2966076+600WP_060847418.1L,D-transpeptidase-
Maq22A_RS135752966325..2966774+450WP_060847419.1hypothetical protein-
Maq22A_RS135802966880..2967284-405WP_060847420.1type II toxin-antitoxin system VapC family toxinToxin
Maq22A_RS135852967281..2967538-258WP_099053403.1antitoxinAntitoxin
Maq22A_RS135902967799..2968248+450WP_060847422.1hypothetical protein-
Maq22A_RS135952968492..2970495+2004WP_060847423.1acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha-
Maq22A_RS136002970513..2970929+417WP_060847424.1gamma-glutamylcyclotransferase-
Maq22A_RS136052971258..2971680-423WP_060847425.1phosphoribosyl-AMP cyclohydrolase-
Maq22A_RS136102971677..2972336-660WP_060847426.1GTP cyclohydrolase I FolE-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-127)

Antitoxin

(16-58)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 14204.46 Da        Isoelectric Point: 5.1848

>T30877 WP_060847420.1 NZ_AP014704:c2967284-2966880 [Methylobacterium aquaticum]
MSGPRFLLDTSILSDLIRNPSGAVARQIARVGSKGIATSIVSVAELRYGCAKRGSARLLLQVEAVLEAIDVVPFEAPADV
IYGRIRADLEAAGRPIGPNDLLIAAQALALEVPLVTANEAEFRRVGGLTVENWL

Download         Length: 405 bp

>T30877 NZ_AP014704:c2967284-2966880 [Methylobacterium aquaticum]
ATGAGCGGCCCACGCTTCCTGCTCGATACGAGCATCCTCTCCGATCTGATCCGCAACCCGTCCGGTGCCGTCGCCCGGCA
GATCGCCCGGGTCGGTAGCAAAGGCATCGCGACGAGCATCGTCTCGGTTGCGGAACTCCGCTACGGCTGCGCGAAGCGGG
GGTCGGCCCGCCTTCTCCTTCAGGTCGAAGCCGTCCTGGAGGCGATCGACGTGGTTCCGTTCGAGGCTCCCGCCGATGTC
ATCTACGGACGAATTCGCGCCGATCTCGAGGCTGCGGGTCGGCCGATCGGGCCGAACGATCTCCTCATCGCCGCTCAGGC
GCTCGCGCTCGAGGTTCCGCTCGTGACGGCGAACGAGGCGGAGTTTCGGCGCGTCGGCGGGCTGACGGTCGAGAACTGGC
TCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9642.01 Da        Isoelectric Point: 4.3115

>AT30877 WP_099053403.1 NZ_AP014704:c2967538-2967281 [Methylobacterium aquaticum]
MARPTPIPQPREVKLFRNNRSQAVRIPAEFALPGDRVRISRDGDRLILEPIGKKDLLEVLATLESIEEDFPDLDETLPPL
DDDPL

Download         Length: 258 bp

>AT30877 NZ_AP014704:c2967538-2967281 [Methylobacterium aquaticum]
ATGGCGAGACCGACCCCGATACCGCAGCCGCGCGAGGTGAAGCTGTTCCGCAACAATCGGAGCCAGGCCGTGCGCATCCC
GGCCGAGTTCGCCTTGCCCGGAGACCGGGTCCGCATCAGCCGCGATGGCGACCGCCTCATCCTGGAGCCGATCGGCAAGA
AGGACCTTCTGGAGGTCCTGGCGACCCTGGAGTCGATCGAGGAGGATTTCCCGGACCTCGACGAGACGCTGCCGCCTCTG
GACGATGATCCGCTATGA

Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0C6FCQ3


Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References