Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-VagC |
Location | 2966880..2967538 | Replicon | chromosome |
Accession | NZ_AP014704 | ||
Organism | Methylobacterium aquaticum strain MA-22A |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0C6FCQ3 |
Locus tag | Maq22A_RS13580 | Protein ID | WP_060847420.1 |
Coordinates | 2966880..2967284 (-) | Length | 135 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | Maq22A_RS13585 | Protein ID | WP_099053403.1 |
Coordinates | 2967281..2967538 (-) | Length | 86 a.a. |
Genomic Context
Location: 2963143..2964231 (1089 bp)
Type: Others
Protein ID: WP_060849395.1
Type: Others
Protein ID: WP_060849395.1
Location: 2965477..2966076 (600 bp)
Type: Others
Protein ID: WP_060847418.1
Type: Others
Protein ID: WP_060847418.1
Location: 2966325..2966774 (450 bp)
Type: Others
Protein ID: WP_060847419.1
Type: Others
Protein ID: WP_060847419.1
Location: 2967799..2968248 (450 bp)
Type: Others
Protein ID: WP_060847422.1
Type: Others
Protein ID: WP_060847422.1
Location: 2968492..2970495 (2004 bp)
Type: Others
Protein ID: WP_060847423.1
Type: Others
Protein ID: WP_060847423.1
Location: 2970513..2970929 (417 bp)
Type: Others
Protein ID: WP_060847424.1
Type: Others
Protein ID: WP_060847424.1
Location: 2964351..2965280 (930 bp)
Type: Others
Protein ID: WP_060847417.1
Type: Others
Protein ID: WP_060847417.1
Location: 2966880..2967284 (405 bp)
Type: Toxin
Protein ID: WP_060847420.1
Type: Toxin
Protein ID: WP_060847420.1
Location: 2967281..2967538 (258 bp)
Type: Antitoxin
Protein ID: WP_099053403.1
Type: Antitoxin
Protein ID: WP_099053403.1
Location: 2971258..2971680 (423 bp)
Type: Others
Protein ID: WP_060847425.1
Type: Others
Protein ID: WP_060847425.1
Location: 2971677..2972336 (660 bp)
Type: Others
Protein ID: WP_060847426.1
Type: Others
Protein ID: WP_060847426.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
Maq22A_RS13560 | 2963143..2964231 | + | 1089 | WP_060849395.1 | 3,4-dihydroxy-2-butanone-4-phosphate synthase | - |
Maq22A_RS13565 | 2964351..2965280 | - | 930 | WP_060847417.1 | histone deacetylase family protein | - |
Maq22A_RS13570 | 2965477..2966076 | + | 600 | WP_060847418.1 | L,D-transpeptidase | - |
Maq22A_RS13575 | 2966325..2966774 | + | 450 | WP_060847419.1 | hypothetical protein | - |
Maq22A_RS13580 | 2966880..2967284 | - | 405 | WP_060847420.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
Maq22A_RS13585 | 2967281..2967538 | - | 258 | WP_099053403.1 | antitoxin | Antitoxin |
Maq22A_RS13590 | 2967799..2968248 | + | 450 | WP_060847422.1 | hypothetical protein | - |
Maq22A_RS13595 | 2968492..2970495 | + | 2004 | WP_060847423.1 | acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha | - |
Maq22A_RS13600 | 2970513..2970929 | + | 417 | WP_060847424.1 | gamma-glutamylcyclotransferase | - |
Maq22A_RS13605 | 2971258..2971680 | - | 423 | WP_060847425.1 | phosphoribosyl-AMP cyclohydrolase | - |
Maq22A_RS13610 | 2971677..2972336 | - | 660 | WP_060847426.1 | GTP cyclohydrolase I FolE | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14204.46 Da Isoelectric Point: 5.1848
>T30877 WP_060847420.1 NZ_AP014704:c2967284-2966880 [Methylobacterium aquaticum]
MSGPRFLLDTSILSDLIRNPSGAVARQIARVGSKGIATSIVSVAELRYGCAKRGSARLLLQVEAVLEAIDVVPFEAPADV
IYGRIRADLEAAGRPIGPNDLLIAAQALALEVPLVTANEAEFRRVGGLTVENWL
MSGPRFLLDTSILSDLIRNPSGAVARQIARVGSKGIATSIVSVAELRYGCAKRGSARLLLQVEAVLEAIDVVPFEAPADV
IYGRIRADLEAAGRPIGPNDLLIAAQALALEVPLVTANEAEFRRVGGLTVENWL
Download Length: 405 bp
>T30877 NZ_AP014704:c2967284-2966880 [Methylobacterium aquaticum]
ATGAGCGGCCCACGCTTCCTGCTCGATACGAGCATCCTCTCCGATCTGATCCGCAACCCGTCCGGTGCCGTCGCCCGGCA
GATCGCCCGGGTCGGTAGCAAAGGCATCGCGACGAGCATCGTCTCGGTTGCGGAACTCCGCTACGGCTGCGCGAAGCGGG
GGTCGGCCCGCCTTCTCCTTCAGGTCGAAGCCGTCCTGGAGGCGATCGACGTGGTTCCGTTCGAGGCTCCCGCCGATGTC
ATCTACGGACGAATTCGCGCCGATCTCGAGGCTGCGGGTCGGCCGATCGGGCCGAACGATCTCCTCATCGCCGCTCAGGC
GCTCGCGCTCGAGGTTCCGCTCGTGACGGCGAACGAGGCGGAGTTTCGGCGCGTCGGCGGGCTGACGGTCGAGAACTGGC
TCTAA
ATGAGCGGCCCACGCTTCCTGCTCGATACGAGCATCCTCTCCGATCTGATCCGCAACCCGTCCGGTGCCGTCGCCCGGCA
GATCGCCCGGGTCGGTAGCAAAGGCATCGCGACGAGCATCGTCTCGGTTGCGGAACTCCGCTACGGCTGCGCGAAGCGGG
GGTCGGCCCGCCTTCTCCTTCAGGTCGAAGCCGTCCTGGAGGCGATCGACGTGGTTCCGTTCGAGGCTCCCGCCGATGTC
ATCTACGGACGAATTCGCGCCGATCTCGAGGCTGCGGGTCGGCCGATCGGGCCGAACGATCTCCTCATCGCCGCTCAGGC
GCTCGCGCTCGAGGTTCCGCTCGTGACGGCGAACGAGGCGGAGTTTCGGCGCGTCGGCGGGCTGACGGTCGAGAACTGGC
TCTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9642.01 Da Isoelectric Point: 4.3115
>AT30877 WP_099053403.1 NZ_AP014704:c2967538-2967281 [Methylobacterium aquaticum]
MARPTPIPQPREVKLFRNNRSQAVRIPAEFALPGDRVRISRDGDRLILEPIGKKDLLEVLATLESIEEDFPDLDETLPPL
DDDPL
MARPTPIPQPREVKLFRNNRSQAVRIPAEFALPGDRVRISRDGDRLILEPIGKKDLLEVLATLESIEEDFPDLDETLPPL
DDDPL
Download Length: 258 bp
>AT30877 NZ_AP014704:c2967538-2967281 [Methylobacterium aquaticum]
ATGGCGAGACCGACCCCGATACCGCAGCCGCGCGAGGTGAAGCTGTTCCGCAACAATCGGAGCCAGGCCGTGCGCATCCC
GGCCGAGTTCGCCTTGCCCGGAGACCGGGTCCGCATCAGCCGCGATGGCGACCGCCTCATCCTGGAGCCGATCGGCAAGA
AGGACCTTCTGGAGGTCCTGGCGACCCTGGAGTCGATCGAGGAGGATTTCCCGGACCTCGACGAGACGCTGCCGCCTCTG
GACGATGATCCGCTATGA
ATGGCGAGACCGACCCCGATACCGCAGCCGCGCGAGGTGAAGCTGTTCCGCAACAATCGGAGCCAGGCCGTGCGCATCCC
GGCCGAGTTCGCCTTGCCCGGAGACCGGGTCCGCATCAGCCGCGATGGCGACCGCCTCATCCTGGAGCCGATCGGCAAGA
AGGACCTTCTGGAGGTCCTGGCGACCCTGGAGTCGATCGAGGAGGATTTCCCGGACCTCGACGAGACGCTGCCGCCTCTG
GACGATGATCCGCTATGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0C6FCQ3 |
Antitoxin
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Source | ID | Structure |
---|---|---|
No matching records found |