Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1297058..1297911 Replicon chromosome
Accession NZ_AP014658
Organism Bifidobacterium longum strain 105-A

Toxin (Protein)


Gene name relE Uniprot ID A0A0A1GSH6
Locus tag BL105A_RS05520 Protein ID WP_041080654.1
Coordinates 1297058..1297549 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A1GRX0
Locus tag BL105A_RS05525 Protein ID WP_041080656.1
Coordinates 1297549..1297911 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL105A_RS05500 1292128..1293360 + 1233 WP_007056207.1 sensor histidine kinase -
BL105A_RS05505 1293395..1294120 + 726 WP_007056206.1 response regulator transcription factor -
BL105A_RS05510 1294160..1294801 + 642 WP_007052627.1 GNAT family N-acetyltransferase -
BL105A_RS05515 1294891..1296996 + 2106 WP_041080652.1 DUF262 domain-containing protein -
BL105A_RS05520 1297058..1297549 - 492 WP_041080654.1 PIN domain-containing protein Toxin
BL105A_RS05525 1297549..1297911 - 363 WP_041080656.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BL105A_RS05530 1298056..1300755 - 2700 WP_007054466.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18307.84 Da        Isoelectric Point: 4.4719

>T30869 WP_041080654.1 NZ_AP014658:c1297549-1297058 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAESVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKSNESEVENFTRSF
LSSRVPWHCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISLFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T30869 NZ_AP014658:c1297549-1297058 [Bifidobacterium longum]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTTGATACCAATGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAATCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAATCGAATGAATCGGAAGTGGAGAATTTCACTCGAAGCTTT
CTGTCGTCACGGGTGCCATGGCATTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCTTTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14002.08 Da        Isoelectric Point: 5.0733

>AT30869 WP_041080656.1 NZ_AP014658:c1297911-1297549 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRVD

Download         Length: 363 bp

>AT30869 NZ_AP014658:c1297911-1297549 [Bifidobacterium longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCCTTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTACACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGTCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1GSH6

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1GRX0

References