Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2115382..2115896 Replicon chromosome
Accession NZ_AP014652
Organism Staphylococcus aureus strain TMUS2126

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag SAJPND1_RS10650 Protein ID WP_000581792.1
Coordinates 2115382..2115591 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag SAJPND1_RS10655 Protein ID WP_000138932.1
Coordinates 2115603..2115896 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAJPND1_RS10630 2110890..2112248 - 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SAJPND1_RS10635 2112263..2113333 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
SAJPND1_RS10640 2113651..2114853 + 1203 WP_020978293.1 rod shape-determining protein RodA -
SAJPND1_RS10645 2115117..2115254 - 138 WP_000828354.1 hypothetical protein -
SAJPND1_RS10650 2115382..2115591 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
SAJPND1_RS10655 2115603..2115896 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAJPND1_RS10660 2116062..2117547 + 1486 Protein_2007 cardiolipin synthase -
SAJPND1_RS10665 2117575..2118222 + 648 WP_001187630.1 HD domain-containing protein -
SAJPND1_RS10675 2118694..2119566 - 873 WP_000725802.1 membrane protein insertase YidC -
SAJPND1_RS10680 2119652..2120293 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2109449..2110621 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T30847 WP_000581792.1 NZ_AP014652:c2115591-2115382 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T30847 NZ_AP014652:c2115591-2115382 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT30847 WP_000138932.1 NZ_AP014652:c2115896-2115603 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT30847 NZ_AP014652:c2115896-2115603 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References