Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 837995..838472 Replicon chromosome
Accession NZ_AP014652
Organism Staphylococcus aureus strain TMUS2126

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAJPND1_RS04095 Protein ID WP_000052076.1
Coordinates 837995..838183 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAJPND1_RS04100 Protein ID WP_001059690.1
Coordinates 838212..838472 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAJPND1_RS04065 833985..834506 + 522 WP_000824484.1 hypothetical protein -
SAJPND1_RS04070 834847..835533 + 687 WP_001792695.1 thermonuclease family protein -
SAJPND1_RS04075 835890..836090 + 201 WP_001059082.1 cold-shock protein -
SAJPND1_RS04080 836586..836804 - 219 WP_000005886.1 hypothetical protein -
SAJPND1_RS04085 836866..837150 - 285 WP_001004395.1 hypothetical protein -
SAJPND1_RS04090 837238..837807 - 570 WP_001106654.1 hypothetical protein -
SAJPND1_RS04095 837995..838183 - 189 WP_000052076.1 hypothetical protein Toxin
SAJPND1_RS04100 838212..838472 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAJPND1_RS04105 838813..839016 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAJPND1_RS04110 839013..839249 - 237 WP_000368687.1 hypothetical protein -
SAJPND1_RS04115 839474..840055 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAJPND1_RS04120 840128..840745 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAJPND1_RS04125 840900..841394 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAJPND1_RS04130 841793..842215 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAJPND1_RS04135 842363..843079 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T30839 WP_000052076.1 NZ_AP014652:c838183-837995 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T30839 NZ_AP014652:c838183-837995 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT30839 WP_001059690.1 NZ_AP014652:c838472-838212 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT30839 NZ_AP014652:c838472-838212 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References