Detailed information of TA system TA030832

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2877444..2878123
• Replicon: chromosome
• Accession: NZ_AP014649
• Organism: Acinetobacter baumannii strain IOMTU433

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: IOMTU433_RS13650
• Protein ID: WP_000838146.1
• Coordinates: 2877941..2878123 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: IOMTU433_RS13645
• Protein ID: WP_000966688.1
• Coordinates: 2877444..2877848 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOMTU433_RS13635	2876400..2876663	-	264	WP_001275792.1	hypothetical protein	-
IOMTU433_RS13640	2876665..2877345	-	681	WP_000721572.1	hypothetical protein	-
IOMTU433_RS13645	2877444..2877848	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IOMTU433_RS13650	2877941..2878123	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
IOMTU433_RS13655	2878449..2878964	-	516	WP_001185592.1	hypothetical protein	-
IOMTU433_RS13660	2879034..2879951	-	918	WP_000094273.1	hypothetical protein	-
IOMTU433_RS13665	2880004..2880975	-	972	WP_032051761.1	hypothetical protein	-
IOMTU433_RS13670	2880975..2881328	-	354	WP_032051762.1	hypothetical protein	-
IOMTU433_RS13675	2881424..2881642	-	219	WP_002002228.1	hypothetical protein	-
IOMTU433_RS13680	2881644..2882042	-	399	WP_002062850.1	hypothetical protein	-
IOMTU433_RS13685	2882044..2882412	-	369	WP_001993865.1	hypothetical protein	-
IOMTU433_RS13690	2882384..2882788	-	405	WP_045544425.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2861974..2907361	45387

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T30832 WP_000838146.1 NZ_AP014649:c2878123-2877941 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T30832 NZ_AP014649:c2878123-2877941 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT30832 WP_000966688.1 NZ_AP014649:c2877848-2877444 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT30832 NZ_AP014649:c2877848-2877444 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6