Detailed information of TA system TA030831

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1938545..1940181
• Replicon: chromosome
• Accession: NZ_AP014649
• Organism: Acinetobacter baumannii strain IOMTU433

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A090B5R1
• Locus tag: IOMTU433_RS09200
• Protein ID: WP_045544121.1
• Coordinates: 1938545..1939876 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IOMTU433_RS09205
• Protein ID: WP_001101310.1
• Coordinates: 1939873..1940181 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOMTU433_RS09175	1933626..1934864	+	1239	WP_087486657.1	TolC family protein	-
IOMTU433_RS09180	1934857..1936020	+	1164	WP_045544117.1	hypothetical protein	-
IOMTU433_RS09185	1936147..1937118	+	972	WP_087486613.1	acid phosphatase	-
IOMTU433_RS09190	1937130..1937774	+	645	WP_045544119.1	hypothetical protein	-
IOMTU433_RS09195	1937809..1938249	-	441	WP_045544120.1	HD domain-containing protein	-
IOMTU433_RS09200	1938545..1939876	+	1332	WP_045544121.1	type II toxin-antitoxin system HipA family toxin	Toxin
IOMTU433_RS09205	1939873..1940181	+	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
IOMTU433_RS09210	1940904..1941452	+	549	WP_045544122.1	TetR/AcrR family transcriptional regulator	-
IOMTU433_RS09215	1941646..1943343	+	1698	WP_045544123.1	AAA family ATPase	-
IOMTU433_RS09220	1943348..1944973	+	1626	WP_045544124.1	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.29 Da
• Isoelectric Point: 4.9177

>T30831 WP_045544121.1 NZ_AP014649:1938545-1939876 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T30831 NZ_AP014649:1938545-1939876 [Acinetobacter baumannii]
ATGAAAAAATTAACGATACAAGCTTTACTAAATAAAAACTGGATAGATATAGCAGAACTAAAACTGCTGGAACCTAAGTT
GGGTTCGGCTAGCGCCAGTGAACTAGAATATGAATTGGATTATGCAATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACATGAATCGGACACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGGATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGC
ACTTACGTTATTTTAGTAAGGAAGATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATT
AGTGGTGGTGCAACTGGTGCTGGCGGGGAAGCTCCCAAATTACTTATTCGTGTTTCACCGGAACAAAAAGTCTGGATTGA
CACCTACCAAGAAAAATTTGATCAGCCAGATCAGCATTATTTGGTGAAATTCCCGCGAAATAAACGTAGCGAGATTGATT
GCGATATTCTCAGAGCCGAATATTATTACTATCAAATACTCAATGAGTTAGGTTTCAACACAATTGAAACAACCCAAATG
AAGCTCATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTGTTTGTGAGTGGTTACAACGCGACTTACTC
AATATCATTTTTGGCAATTCAGATAACCACGGTCGTAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCGGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTACGAGGAAG
GTGGTGAATACCGGTGGGCGCAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCGACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCCAAACAAATTATTGAAATGCCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT30831 WP_001101310.1 NZ_AP014649:1939873-1940181 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT30831 NZ_AP014649:1939873-1940181 [Acinetobacter baumannii]
ATGAATGTAAAAAATCAAACCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTATCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAGCCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAACGAGTAA

Structures

Toxin

• AlphaFold DB: A0A090B5R1