Detailed information of TA system TA030830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1634878..1635557
• Replicon: chromosome
• Accession: NZ_AP014649
• Organism: Acinetobacter baumannii strain IOMTU433

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: IOMTU433_RS07740
• Protein ID: WP_000838146.1
• Coordinates: 1634878..1635060 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: IOMTU433_RS07745
• Protein ID: WP_000966688.1
• Coordinates: 1635153..1635557 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOMTU433_RS07700	1629958..1630326	+	369	WP_032016325.1	hypothetical protein	-
IOMTU433_RS07705	1630328..1630726	+	399	WP_045544022.1	hypothetical protein	-
IOMTU433_RS07710	1630728..1630946	+	219	WP_002132566.1	hypothetical protein	-
IOMTU433_RS07715	1631055..1631576	+	522	WP_002055493.1	SH3 domain-containing protein	-
IOMTU433_RS07720	1631673..1632026	+	354	WP_002055486.1	hypothetical protein	-
IOMTU433_RS07725	1632026..1632997	+	972	WP_045544023.1	hypothetical protein	-
IOMTU433_RS07730	1633050..1633967	+	918	WP_042774720.1	hypothetical protein	-
IOMTU433_RS07735	1634037..1634552	+	516	WP_009517104.1	hypothetical protein	-
IOMTU433_RS07740	1634878..1635060	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
IOMTU433_RS07745	1635153..1635557	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IOMTU433_RS07750	1635657..1636166	+	510	WP_000735548.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1604448..1657642	53194

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T30830 WP_000838146.1 NZ_AP014649:1634878-1635060 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T30830 NZ_AP014649:1634878-1635060 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT30830 WP_000966688.1 NZ_AP014649:1635153-1635557 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT30830 NZ_AP014649:1635153-1635557 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6