Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 462418..463071 Replicon chromosome
Accession NZ_AP014649
Organism Acinetobacter baumannii strain IOMTU433

Toxin (Protein)


Gene name cptA Uniprot ID A0A246A3V9
Locus tag IOMTU433_RS02250 Protein ID WP_002054941.1
Coordinates 462682..463071 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag IOMTU433_RS02245 Protein ID WP_001288210.1
Coordinates 462418..462675 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOMTU433_RS02225 457933..458940 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
IOMTU433_RS02230 458959..459336 + 378 WP_001216380.1 50S ribosomal protein L17 -
IOMTU433_RS02235 459518..461008 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
IOMTU433_RS02240 461058..462230 - 1173 WP_045543714.1 acyl-CoA dehydrogenase family protein -
IOMTU433_RS02245 462418..462675 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
IOMTU433_RS02250 462682..463071 + 390 WP_002054941.1 hypothetical protein Toxin
IOMTU433_RS02255 463841..464926 + 1086 WP_000049106.1 hypothetical protein -
IOMTU433_RS02260 465004..465570 + 567 WP_000651536.1 rhombosortase -
IOMTU433_RS02265 465758..467953 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15616.87 Da        Isoelectric Point: 10.2790

>T30829 WP_002054941.1 NZ_AP014649:462682-463071 [Acinetobacter baumannii]
MINHLNFKLKYSHFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T30829 NZ_AP014649:462682-463071 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCATTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT30829 WP_001288210.1 NZ_AP014649:462418-462675 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT30829 NZ_AP014649:462418-462675 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246A3V9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References