Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/DUF433(antitoxin) |
Location | 4796350..4796912 | Replicon | chromosome |
Accession | NZ_AP014638 | ||
Organism | Leptolyngbya boryana IAM M-101 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A1Z4JEA4 |
Locus tag | LBWT_RS22795 | Protein ID | WP_017286620.1 |
Coordinates | 4796350..4796691 (-) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A1Z4JEC0 |
Locus tag | LBWT_RS22800 | Protein ID | WP_017286619.1 |
Coordinates | 4796688..4796912 (-) | Length | 75 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LBWT_RS22770 | 4791517..4792227 | + | 711 | WP_017286625.1 | ABC transporter ATP-binding protein | - |
LBWT_RS22775 | 4792292..4793476 | + | 1185 | WP_017286624.1 | ABC transporter substrate-binding protein | - |
LBWT_RS22780 | 4793518..4794468 | + | 951 | WP_017286623.1 | branched-chain amino acid ABC transporter permease | - |
LBWT_RS22785 | 4794465..4795391 | + | 927 | WP_017286622.1 | branched-chain amino acid ABC transporter permease | - |
LBWT_RS22790 | 4795484..4796305 | + | 822 | WP_017286621.1 | slipin family protein | - |
LBWT_RS22795 | 4796350..4796691 | - | 342 | WP_017286620.1 | DUF5615 family PIN-like protein | Toxin |
LBWT_RS22800 | 4796688..4796912 | - | 225 | WP_017286619.1 | DUF433 domain-containing protein | Antitoxin |
LBWT_RS22805 | 4797123..4797809 | + | 687 | WP_017286618.1 | SEC59/DGK1/VTE5 family protein | - |
LBWT_RS22810 | 4797859..4799493 | + | 1635 | WP_017286617.1 | ABC transporter ATP-binding protein | - |
LBWT_RS22815 | 4799559..4800248 | + | 690 | WP_017286616.1 | glycoside hydrolase family protein | - |
LBWT_RS32060 | 4800654..4800818 | + | 165 | WP_017286615.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12378.18 Da Isoelectric Point: 4.1314
>T30816 WP_017286620.1 NZ_AP014638:c4796691-4796350 [Leptolyngbya boryana IAM M-101]
VTTIWIDAHLSPVIATWITGRFGITAIALRDIGLRDAEDPEIFEAAKAQGVIFMTKDSDFVDLVERLEAPPQIIWLTCGN
TSNARLQEILSSTLPDALELLKSGEKLVEISGE
VTTIWIDAHLSPVIATWITGRFGITAIALRDIGLRDAEDPEIFEAAKAQGVIFMTKDSDFVDLVERLEAPPQIIWLTCGN
TSNARLQEILSSTLPDALELLKSGEKLVEISGE
Download Length: 342 bp
>T30816 NZ_AP014638:c4796691-4796350 [Leptolyngbya boryana IAM M-101]
GTGACAACGATTTGGATCGATGCCCATTTGTCGCCTGTGATCGCAACTTGGATTACAGGCAGATTTGGAATTACCGCGAT
CGCTTTACGGGATATCGGCTTGAGAGATGCCGAAGATCCCGAAATCTTTGAGGCTGCAAAAGCTCAAGGCGTTATATTCA
TGACTAAAGATAGCGATTTCGTGGATCTCGTTGAACGTTTGGAAGCACCGCCACAAATTATTTGGTTAACTTGTGGCAAT
ACATCAAATGCCCGTTTGCAGGAAATTCTAAGCTCGACTTTGCCTGATGCATTAGAGTTATTGAAATCTGGCGAAAAGCT
AGTAGAGATTAGCGGAGAGTAA
GTGACAACGATTTGGATCGATGCCCATTTGTCGCCTGTGATCGCAACTTGGATTACAGGCAGATTTGGAATTACCGCGAT
CGCTTTACGGGATATCGGCTTGAGAGATGCCGAAGATCCCGAAATCTTTGAGGCTGCAAAAGCTCAAGGCGTTATATTCA
TGACTAAAGATAGCGATTTCGTGGATCTCGTTGAACGTTTGGAAGCACCGCCACAAATTATTTGGTTAACTTGTGGCAAT
ACATCAAATGCCCGTTTGCAGGAAATTCTAAGCTCGACTTTGCCTGATGCATTAGAGTTATTGAAATCTGGCGAAAAGCT
AGTAGAGATTAGCGGAGAGTAA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8186.57 Da Isoelectric Point: 7.8330
>AT30816 WP_017286619.1 NZ_AP014638:c4796912-4796688 [Leptolyngbya boryana IAM M-101]
MSDLLKRITVNPKQCGGRPCIRGMRIRVSDVLDLFAAGLSAEQILEELPDLERDDLRAALAYASRKVNHPVLVA
MSDLLKRITVNPKQCGGRPCIRGMRIRVSDVLDLFAAGLSAEQILEELPDLERDDLRAALAYASRKVNHPVLVA
Download Length: 225 bp
>AT30816 NZ_AP014638:c4796912-4796688 [Leptolyngbya boryana IAM M-101]
ATGTCAGACTTACTTAAACGAATCACCGTGAATCCTAAGCAATGTGGGGGTCGCCCCTGTATTCGTGGCATGAGAATTCG
AGTGTCCGATGTTTTGGATTTATTTGCAGCAGGGTTAAGTGCTGAACAAATTTTGGAAGAACTGCCTGATCTGGAAAGAG
ATGATTTAAGAGCAGCACTTGCCTACGCTTCACGTAAAGTCAACCACCCTGTTTTAGTCGCGTGA
ATGTCAGACTTACTTAAACGAATCACCGTGAATCCTAAGCAATGTGGGGGTCGCCCCTGTATTCGTGGCATGAGAATTCG
AGTGTCCGATGTTTTGGATTTATTTGCAGCAGGGTTAAGTGCTGAACAAATTTTGGAAGAACTGCCTGATCTGGAAAGAG
ATGATTTAAGAGCAGCACTTGCCTACGCTTCACGTAAAGTCAACCACCCTGTTTTAGTCGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Z4JEA4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Z4JEC0 |