Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3651852..3652542 Replicon chromosome
Accession NZ_AP014637
Organism Pseudomonas sp. StFLB209

Toxin (Protein)


Gene name hicA Uniprot ID A0A077LJ78
Locus tag PSCI_RS16340 Protein ID WP_045488915.1
Coordinates 3652360..3652542 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A077LH96
Locus tag PSCI_RS16335 Protein ID WP_045488912.1
Coordinates 3651852..3652253 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSCI_RS16310 3646913..3647839 + 927 WP_045488898.1 hypothetical protein -
PSCI_RS16315 3647836..3648387 + 552 WP_045488900.1 hypothetical protein -
PSCI_RS16320 3648384..3649079 + 696 WP_045488903.1 hypothetical protein -
PSCI_RS16325 3649064..3650035 + 972 WP_045488906.1 hypothetical protein -
PSCI_RS16330 3650266..3650961 - 696 WP_045488909.1 hypothetical protein -
PSCI_RS28680 3651443..3651673 + 231 WP_177328608.1 adenine modification methytransferase -
PSCI_RS16335 3651852..3652253 - 402 WP_045488912.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PSCI_RS16340 3652360..3652542 - 183 WP_045488915.1 type II toxin-antitoxin system HicA family toxin Toxin
PSCI_RS16345 3652624..3652965 - 342 WP_045488917.1 hypothetical protein -
PSCI_RS16350 3653160..3653618 + 459 WP_045488920.1 hypothetical protein -
PSCI_RS16355 3654088..3655983 + 1896 WP_045488922.1 potassium transporter Kup -
PSCI_RS16360 3656042..3657379 - 1338 WP_045488925.1 virulence factor family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3620293..3653618 33325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6825.93 Da        Isoelectric Point: 10.5440

>T30809 WP_045488915.1 NZ_AP014637:c3652542-3652360 [Pseudomonas sp. StFLB209]
MRSRDMMKLIEEDGWYLVATKGSHHQYKHPTKKGRVTIAHPNSDIPIGTINNILKQAGLK

Download         Length: 183 bp

>T30809 NZ_AP014637:c3652542-3652360 [Pseudomonas sp. StFLB209]
ATGCGAAGCCGGGATATGATGAAGCTGATCGAGGAGGATGGTTGGTATCTGGTGGCTACTAAAGGTAGCCATCATCAGTA
CAAACATCCTACCAAAAAGGGGCGGGTCACGATTGCACACCCAAATTCCGACATCCCTATTGGCACTATCAACAACATCC
TAAAACAAGCCGGTCTGAAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14710.44 Da        Isoelectric Point: 4.3947

>AT30809 WP_045488912.1 NZ_AP014637:c3652253-3651852 [Pseudomonas sp. StFLB209]
MKFPVVLHKDSNTDFGVTIPDVPRCFSAGATFEEALDNVREALALHFEGLVEDDEELPEAASIESHITNPEYQGGIWAVV
EFDVTPYSGKAVRFNATLPEKLLSRIDERVKQDSRYASRSGFLASAALHELSI

Download         Length: 402 bp

>AT30809 NZ_AP014637:c3652253-3651852 [Pseudomonas sp. StFLB209]
ATGAAATTTCCAGTAGTTTTACACAAAGACAGCAATACAGATTTTGGCGTGACAATTCCTGACGTCCCAAGATGTTTCAG
CGCTGGAGCCACCTTCGAGGAGGCACTGGACAACGTACGGGAAGCGTTAGCGCTACATTTCGAAGGTTTGGTCGAGGATG
ACGAAGAACTTCCTGAGGCCGCATCTATCGAAAGCCACATTACAAACCCTGAGTATCAAGGCGGCATTTGGGCAGTCGTA
GAGTTCGACGTAACCCCCTACTCTGGTAAAGCCGTTCGATTTAATGCAACGTTACCTGAGAAGCTTCTCAGCCGCATTGA
CGAACGAGTGAAGCAAGACAGCCGATACGCGTCCCGTTCCGGTTTTCTCGCAAGCGCAGCACTGCACGAACTCTCAATCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A077LJ78

Antitoxin

Source ID Structure
AlphaFold DB A0A077LH96

References