Detailed information of TA system TA030794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 4099071..4099726
• Replicon: chromosome
• Accession: NZ_AP014628
• Organism: Pseudomonas sp. St29

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0D6BKI7
• Locus tag: PST29_RS18170
• Protein ID: WP_060839909.1
• Coordinates: 4099071..4099250 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PST29_RS18175
• Protein ID: WP_060843957.1
• Coordinates: 4099301..4099726 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PST29_RS18140	4094296..4094571	+	276	WP_011061856.1	peptidylprolyl isomerase	-
PST29_RS18145	4094680..4095597	-	918	WP_060843953.1	sugar kinase	-
PST29_RS18150	4095744..4096961	-	1218	WP_060843954.1	amino acid deaminase	-
PST29_RS18155	4097009..4097773	-	765	WP_060839906.1	IclR family transcriptional regulator	-
PST29_RS18160	4097893..4098282	-	390	WP_060843955.1	RidA family protein	-
PST29_RS18165	4098715..4098981	+	267	WP_060843956.1	hypothetical protein	-
PST29_RS18170	4099071..4099250	+	180	WP_060839909.1	type II toxin-antitoxin system HicA family toxin	Toxin
PST29_RS18175	4099301..4099726	+	426	WP_060843957.1	transcriptional regulator	Antitoxin
PST29_RS18180	4099798..4100343	-	546	WP_060843958.1	hypothetical protein	-
PST29_RS18185	4100534..4101967	-	1434	WP_060843959.1	RtcB family protein	-
PST29_RS18190	4102145..4102927	-	783	WP_148654982.1	hypothetical protein	-
PST29_RS18195	4103064..4103888	-	825	WP_060843960.1	hypothetical protein	-
PST29_RS18200	4104116..4104688	+	573	WP_060843961.1	glutamine amidotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6632.63 Da
• Isoelectric Point: 11.0565

>T30794 WP_060839909.1 NZ_AP014628:4099071-4099250 [Pseudomonas sp. St29]
MKFSEFRRWLKAQGVVFEAGKGSHFKVTAPNGNQTTFADHGSKEMPEPTRKAIIRQLGL

Nucleotide

• Length: 180 bp

>T30794 NZ_AP014628:4099071-4099250 [Pseudomonas sp. St29]
ATGAAATTCAGCGAATTCAGACGATGGTTGAAAGCTCAAGGCGTGGTCTTCGAGGCCGGTAAAGGCAGCCACTTCAAAGT
TACGGCCCCAAACGGCAACCAGACCACCTTCGCGGATCACGGCAGCAAGGAAATGCCCGAACCCACCCGCAAGGCAATCA
TCAGGCAATTGGGGCTCTAG

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15680.01 Da
• Isoelectric Point: 4.9319

>AT30794 WP_060843957.1 NZ_AP014628:4099301-4099726 [Pseudomonas sp. St29]
MYDYALRFEQDHAPGLAVFCRDLPELNSFGDDPEHAINQAIDALETTLSLYVDQRRAIPPASAPLPGEQVIHLPMVTVAK
IALWNTMMERDMRKADLCRLLGIHQAQGDRLVDFLHSSKMEQLENALAALGKRLAVSVEAA

Nucleotide

• Length: 426 bp

>AT30794 NZ_AP014628:4099301-4099726 [Pseudomonas sp. St29]
ATGTACGACTACGCCCTTCGCTTCGAGCAAGACCATGCACCGGGACTGGCGGTCTTCTGCCGCGATCTGCCCGAACTCAA
TAGCTTTGGCGATGATCCTGAGCACGCCATCAACCAGGCCATCGACGCGCTCGAAACCACTCTGTCCCTTTACGTCGACC
AGCGCCGCGCCATTCCCCCGGCCTCCGCGCCGCTACCAGGGGAACAGGTCATTCATTTGCCAATGGTGACCGTGGCTAAG
ATAGCGCTGTGGAACACGATGATGGAGCGGGACATGCGCAAGGCCGATCTATGCCGACTGCTCGGAATCCACCAGGCCCA
GGGAGATCGCCTGGTGGACTTTCTACACAGCTCCAAAATGGAACAGCTGGAAAATGCCCTGGCAGCCCTGGGTAAACGTC
TTGCGGTATCAGTGGAGGCGGCATAG

Structures

Toxin

• AlphaFold DB: A0A0D6BKI7