Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2400416..2401038 Replicon chromosome
Accession NZ_AP014628
Organism Pseudomonas sp. St29

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PST29_RS10990 Protein ID WP_060845091.1
Coordinates 2400856..2401038 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PST29_RS10985 Protein ID WP_016968754.1
Coordinates 2400416..2400817 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PST29_RS10965 2396043..2396912 + 870 WP_060843048.1 AraC family transcriptional regulator -
PST29_RS10970 2396981..2397235 + 255 WP_060843049.1 hypothetical protein -
PST29_RS10975 2397284..2397640 - 357 WP_060843050.1 hypothetical protein -
PST29_RS10980 2398108..2399733 + 1626 WP_060838487.1 methyl-accepting chemotaxis protein -
PST29_RS10985 2400416..2400817 - 402 WP_016968754.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PST29_RS10990 2400856..2401038 - 183 WP_060845091.1 type II toxin-antitoxin system HicA family toxin Toxin
PST29_RS10995 2401309..2401854 + 546 WP_060843051.1 hypothetical protein -
PST29_RS11000 2402462..2402893 - 432 WP_016968757.1 carboxymuconolactone decarboxylase family protein -
PST29_RS11005 2402922..2403542 - 621 WP_060843052.1 NAD(P)H-dependent oxidoreductase -
PST29_RS11010 2403539..2403985 - 447 WP_060843053.1 GNAT family N-acetyltransferase -
PST29_RS11015 2404073..2405476 + 1404 WP_060843054.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6846.03 Da        Isoelectric Point: 11.1724

>T30792 WP_060845091.1 NZ_AP014628:c2401038-2400856 [Pseudomonas sp. St29]
VQSRQLIKELEAAGWMLERVTGSHHLFQHPYRPDTVPVPHPKKDLPRGTVRAIRKLAGLL

Download         Length: 183 bp

>T30792 NZ_AP014628:c2401038-2400856 [Pseudomonas sp. St29]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCGGGATGGATGCTGGAGCGAGTCACTGGCAGCCATCATCTGTT
CCAGCATCCCTACAGGCCCGACACCGTTCCAGTGCCTCACCCGAAGAAGGATCTGCCCCGGGGAACGGTCAGGGCCATCA
GGAAACTGGCCGGGCTGCTTTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14572.59 Da        Isoelectric Point: 5.5455

>AT30792 WP_016968754.1 NZ_AP014628:c2400817-2400416 [Pseudomonas sp. St29]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEERARAGQAIPLPSPTGKHRTHPDFAGMGWGM
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT30792 NZ_AP014628:c2400817-2400416 [Pseudomonas sp. St29]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAACACACCGCCACCGGCATCCAGATTCCCGACATCCCCGGCGCCGT
CACCGCCGGCGACACCTTCGAGGCCGCCTACAGCGCCGCCATCGAGATTGCCCACGTCATGCTCGAAGAACGGGCCCGAG
CCGGGCAGGCCATTCCCCTGCCCTCGCCCACCGGCAAACACCGCACCCACCCCGATTTCGCGGGCATGGGCTGGGGCATG
CTGGAGATCGACATCACGCCTTACCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCGGGGTATGTGATTCAGCAGAT
CGACCGCTTCGTCCGCGAGCACAACATCAAGAGCCGCTCGTCCTTCCTGGCCGATGCGGCAATGGAAAAGCTCGGGCGCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References