Detailed information of TA system TA030788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 298181..298794
• Replicon: chromosome
• Accession: NZ_AP014628
• Organism: Pseudomonas sp. St29

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PST29_RS01335
• Protein ID: WP_060845057.1
• Coordinates: 298181..298363 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PST29_RS01340
• Protein ID: WP_173664398.1
• Coordinates: 298360..298794 (+)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PST29_RS01320	294266..295192	+	927	WP_041115170.1	serine acetyltransferase	-
PST29_RS01325	295691..297652	+	1962	WP_162492852.1	choline transporter BetT	-
PST29_RS01330	297662..297919	-	258	WP_060837020.1	hypothetical protein	-
PST29_RS01335	298181..298363	+	183	WP_060845057.1	type II toxin-antitoxin system HicA family toxin	Toxin
PST29_RS01340	298360..298794	+	435	WP_173664398.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PST29_RS01345	298797..299843	-	1047	WP_060842166.1	LacI family DNA-binding transcriptional regulator	-
PST29_RS01350	300047..302305	+	2259	WP_060842167.1	TonB-dependent receptor	-
PST29_RS01355	302408..303736	+	1329	WP_060842168.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (14-138)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6831.97 Da
• Isoelectric Point: 10.7495

>T30788 WP_060845057.1 NZ_AP014628:298181-298363 [Pseudomonas sp. St29]
MRSREMIGKIEADGWYLIAVKGSHHQYKHPWKPGRVTIKHPDADLPRGTLNSILKQAGLK

Nucleotide

• Length: 183 bp

>T30788 NZ_AP014628:298181-298363 [Pseudomonas sp. St29]
ATGCGCAGTCGGGAGATGATCGGCAAGATTGAGGCGGATGGTTGGTACCTGATTGCCGTGAAGGGCAGTCACCATCAGTA
CAAGCATCCCTGGAAACCAGGGCGCGTCACTATCAAGCATCCGGATGCGGATCTGCCCAGGGGCACGCTCAACAGCATCT
TGAAACAGGCGGGCTTGAAATGA

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 15922.75 Da
• Isoelectric Point: 4.5688

>AT30788 WP_173664398.1 NZ_AP014628:298360-298794 [Pseudomonas sp. St29]
MSPLLHEESNDMKFPVVLHKDADSEYGVIVPDVPGCYSAGHTVSQAFENVKEALSLHYAGLVADGEPLPQVHEIDEHLDN
PDYAGGVWGVVEFDVTPYFGKSVRFNATLPEHLLERIDQTVKRDQRYNSRSGFLAAAALRELSA

Nucleotide

• Length: 435 bp

>AT30788 NZ_AP014628:298360-298794 [Pseudomonas sp. St29]
ATGAGCCCGTTACTGCATGAGGAGTCCAACGACATGAAATTCCCGGTGGTTCTGCACAAGGATGCCGACTCTGAATACGG
GGTGATCGTTCCGGATGTGCCGGGCTGTTACTCCGCTGGTCACACGGTGTCCCAGGCGTTCGAGAACGTGAAGGAGGCGT
TGTCCCTGCATTACGCAGGGCTGGTGGCCGATGGCGAGCCTCTGCCGCAGGTGCACGAGATCGATGAGCACCTGGACAAC
CCCGACTACGCCGGGGGTGTATGGGGCGTGGTGGAGTTTGACGTGACGCCGTATTTCGGCAAGTCGGTGCGCTTCAATGC
CACCCTGCCGGAACACCTGCTGGAGCGCATCGATCAGACGGTCAAGCGTGACCAGCGCTACAACTCGCGTTCCGGGTTCC
TGGCCGCCGCGGCGCTGCGCGAACTGTCGGCCTGA