Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4198682..4199337 Replicon chromosome
Accession NZ_AP014627
Organism Pseudomonas sp. Os17

Toxin (Protein)


Gene name hicA Uniprot ID A0A0D6BKI7
Locus tag POS17_RS18460 Protein ID WP_060839909.1
Coordinates 4198682..4198861 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0D6BKF7
Locus tag POS17_RS18465 Protein ID WP_060839910.1
Coordinates 4198912..4199337 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
POS17_RS18430 4193907..4194182 + 276 WP_011061856.1 peptidylprolyl isomerase -
POS17_RS18435 4194291..4195208 - 918 WP_060839904.1 sugar kinase -
POS17_RS18440 4195355..4196572 - 1218 WP_060839905.1 amino acid deaminase -
POS17_RS18445 4196620..4197384 - 765 WP_060839906.1 IclR family transcriptional regulator -
POS17_RS18450 4197504..4197893 - 390 WP_060839907.1 RidA family protein -
POS17_RS18455 4198326..4198592 + 267 WP_060839908.1 hypothetical protein -
POS17_RS18460 4198682..4198861 + 180 WP_060839909.1 type II toxin-antitoxin system HicA family toxin Toxin
POS17_RS18465 4198912..4199337 + 426 WP_060839910.1 transcriptional regulator Antitoxin
POS17_RS18470 4199409..4199954 - 546 WP_060839911.1 hypothetical protein -
POS17_RS18475 4200145..4201578 - 1434 WP_060839912.1 RtcB family protein -
POS17_RS18480 4201756..4202538 - 783 WP_148654982.1 hypothetical protein -
POS17_RS18485 4202675..4203499 - 825 WP_060839914.1 hypothetical protein -
POS17_RS18490 4203727..4204299 + 573 WP_060839915.1 glutamine amidotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6632.63 Da        Isoelectric Point: 11.0565

>T30785 WP_060839909.1 NZ_AP014627:4198682-4198861 [Pseudomonas sp. Os17]
MKFSEFRRWLKAQGVVFEAGKGSHFKVTAPNGNQTTFADHGSKEMPEPTRKAIIRQLGL

Download         Length: 180 bp

>T30785 NZ_AP014627:4198682-4198861 [Pseudomonas sp. Os17]
ATGAAATTCAGCGAATTCAGACGATGGTTGAAAGCTCAAGGCGTGGTCTTCGAGGCCGGTAAAGGCAGCCACTTCAAAGT
TACGGCCCCAAACGGCAACCAGACCACCTTCGCGGATCACGGCAGCAAGGAAATGCCCGAACCCACCCGCAAGGCAATCA
TCAGGCAATTGGGGCTCTAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15667.95 Da        Isoelectric Point: 4.9319

>AT30785 WP_060839910.1 NZ_AP014627:4198912-4199337 [Pseudomonas sp. Os17]
MYDYALRFEQDHAPGLAVFCRDLPELNSFGDDPEHATNQAIDALETTLSLYVDQRRAIPPASAPLPGEQVIHLPMVTVAK
IALWNTMMERDMRKADLCRLLGIHQAQGDRLVDFLHSSKMEQLENALAALGKRLAVSVEAA

Download         Length: 426 bp

>AT30785 NZ_AP014627:4198912-4199337 [Pseudomonas sp. Os17]
ATGTACGACTACGCCCTTCGCTTCGAGCAAGACCATGCACCGGGACTGGCGGTCTTCTGCCGCGATCTGCCCGAACTCAA
TAGCTTTGGCGATGATCCTGAGCACGCCACCAACCAGGCCATCGACGCGCTCGAAACCACTCTGTCCCTTTACGTCGACC
AGCGCCGCGCCATTCCCCCGGCCTCCGCGCCGCTACCAGGGGAACAGGTCATTCATTTGCCAATGGTGACCGTGGCCAAG
ATAGCGCTGTGGAACACGATGATGGAGCGGGACATGCGCAAGGCCGATCTATGCCGACTGCTCGGAATCCACCAGGCCCA
GGGAGATCGCCTGGTGGACTTTCTACACAGCTCCAAAATGGAACAGCTGGAAAATGCCCTGGCAGCCCTAGGTAAACGTC
TTGCGGTATCAGTGGAGGCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6BKI7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6BKF7

References