Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2326911..2327533 Replicon chromosome
Accession NZ_AP014627
Organism Pseudomonas sp. Os17

Toxin (Protein)


Gene name hicA Uniprot ID A0A0D6BG24
Locus tag POS17_RS10580 Protein ID WP_047303281.1
Coordinates 2327351..2327533 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0D6BGE8
Locus tag POS17_RS10575 Protein ID WP_060838488.1
Coordinates 2326911..2327312 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
POS17_RS10555 2322527..2323396 + 870 WP_060838484.1 AraC family transcriptional regulator -
POS17_RS10560 2323465..2323719 + 255 WP_060838485.1 hypothetical protein -
POS17_RS10565 2323768..2324124 - 357 WP_060838486.1 hypothetical protein -
POS17_RS10570 2324592..2326217 + 1626 WP_060838487.1 methyl-accepting chemotaxis protein -
POS17_RS10575 2326911..2327312 - 402 WP_060838488.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
POS17_RS10580 2327351..2327533 - 183 WP_047303281.1 type II toxin-antitoxin system HicA family toxin Toxin
POS17_RS10585 2327804..2328349 + 546 WP_060838489.1 hypothetical protein -
POS17_RS10590 2328957..2329388 - 432 WP_060838490.1 carboxymuconolactone decarboxylase family protein -
POS17_RS10595 2329417..2330037 - 621 WP_060838491.1 NAD(P)H-dependent oxidoreductase -
POS17_RS10600 2330034..2330480 - 447 WP_060838492.1 GNAT family N-acetyltransferase -
POS17_RS10605 2330568..2331971 + 1404 WP_060838493.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6813.97 Da        Isoelectric Point: 11.1724

>T30783 WP_047303281.1 NZ_AP014627:c2327533-2327351 [Pseudomonas sp. Os17]
VQSRQLIKELEAAGWVLERVTGSHHLFQHPYRPDTVPVPHPKKDLPRGTVRAIRKLAGLL

Download         Length: 183 bp

>T30783 NZ_AP014627:c2327533-2327351 [Pseudomonas sp. Os17]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCGGGATGGGTGCTGGAGCGAGTCACTGGCAGCCATCATCTGTT
CCAGCATCCCTACAGGCCCGACACCGTTCCAGTGCCTCACCCGAAGAAGGATCTGCCCCGGGGAACGGTCAGGGCCATCA
GGAAACTGGCCGGGCTGCTTTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14602.62 Da        Isoelectric Point: 5.5455

>AT30783 WP_060838488.1 NZ_AP014627:c2327312-2326911 [Pseudomonas sp. Os17]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEERARAGQAIPLPSPTSKHRTHPDFAGMGWGM
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT30783 NZ_AP014627:c2327312-2326911 [Pseudomonas sp. Os17]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAACACACCGCCACCGGCATCCAGATTCCCGACATCCCCGGCGCCGT
CACCGCCGGCGACACCTTCGAGGCCGCCTACAGCGCCGCCATCGAGATTGCCCACGTCATGCTCGAAGAACGGGCCCGAG
CCGGGCAGGCCATTCCCCTGCCCTCGCCCACCAGCAAACACCGCACCCACCCCGATTTCGCGGGCATGGGCTGGGGCATG
CTGGAGATCGACATCACGCCTTACCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCGGGGTATGTGATTCAGCAGAT
CGACCGCTTTGTCCGCGAGCACAACATCAAGAGCCGCTCGTCCTTCCTGGCCGATGCGGCAATGGAAAAGCTCGGGCGCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6BG24

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6BGE8

References