Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 725060..725656 Replicon chromosome
Accession NZ_AP014627
Organism Pseudomonas sp. Os17

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6BAZ3
Locus tag POS17_RS03205 Protein ID WP_060837327.1
Coordinates 725354..725656 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6BB73
Locus tag POS17_RS03200 Protein ID WP_060837326.1
Coordinates 725060..725350 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
POS17_RS03180 721329..723461 - 2133 WP_060837323.1 TonB-dependent copper receptor -
POS17_RS03185 723550..723960 - 411 WP_060837324.1 DUF2946 domain-containing protein -
POS17_RS03190 724018..724497 - 480 WP_173655926.1 copper chaperone PCu(A)C -
POS17_RS03195 724562..724960 - 399 WP_060837325.1 DUF2946 domain-containing protein -
POS17_RS03200 725060..725350 - 291 WP_060837326.1 putative addiction module antidote protein Antitoxin
POS17_RS03205 725354..725656 - 303 WP_060837327.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
POS17_RS03210 725830..726558 - 729 WP_060837328.1 cobalt-precorrin-6A reductase -
POS17_RS03215 726555..727652 - 1098 WP_060837329.1 cobalt-precorrin-5B (C(1))-methyltransferase -
POS17_RS03220 727746..728960 - 1215 WP_060837330.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
POS17_RS03225 729092..730405 + 1314 WP_060837331.1 precorrin-3B synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(5-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11579.35 Da        Isoelectric Point: 10.7047

>T30782 WP_060837327.1 NZ_AP014627:c725656-725354 [Pseudomonas sp. Os17]
MYVFEQTLEFSRWLLHLKDPQGKTRVLARIRAAQLGRFGDCEALGGGVYEMRIHRGPGYRVYFSRRGTVIYLLLIGGDKN
TQRRDIQRARQLAHDLKSEG

Download         Length: 303 bp

>T30782 NZ_AP014627:c725656-725354 [Pseudomonas sp. Os17]
ATGTACGTCTTCGAGCAGACCCTGGAGTTCAGCCGCTGGCTCCTGCACCTGAAGGATCCGCAAGGCAAAACCCGTGTACT
GGCCAGGATCCGCGCCGCCCAACTGGGCCGATTCGGCGACTGCGAAGCACTGGGTGGAGGCGTCTACGAGATGCGCATCC
ATCGTGGTCCCGGCTACCGGGTGTACTTCTCGCGCCGGGGCACGGTGATCTACCTGTTGTTGATCGGCGGTGACAAGAAC
ACCCAGAGACGCGATATCCAACGCGCCAGGCAACTGGCCCACGACCTCAAGAGCGAGGGTTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10466.07 Da        Isoelectric Point: 6.4594

>AT30782 WP_060837326.1 NZ_AP014627:c725350-725060 [Pseudomonas sp. Os17]
MHTPVTRFDAAEYLKTPEDMVAYLDACFEEDIGDGKLIRAALNDIARARGMTQIARDTGLGRESLYKALGSQGNPEFATI
IKVMKALGLKLHVSPA

Download         Length: 291 bp

>AT30782 NZ_AP014627:c725350-725060 [Pseudomonas sp. Os17]
ATGCACACCCCAGTCACCCGCTTCGACGCGGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACATCGGCGACGGCAAGCTGATCCGCGCCGCCCTCAACGATATCGCCCGCGCCCGCGGCATGACCCAGA
TCGCCCGCGATACCGGCCTGGGCCGCGAGAGCCTGTACAAGGCCCTGGGCAGCCAGGGCAATCCCGAGTTCGCAACTATC
ATCAAGGTCATGAAAGCGCTCGGGCTCAAGCTCCACGTCAGCCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6BAZ3

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6BB73

References