Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2205591..2206210 Replicon chromosome
Accession NZ_AP014623
Organism Pseudomonas chlororaphis subsp. aurantiaca strain StFRB508

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G7DMG3
Locus tag PCAU_RS10335 Protein ID WP_009048155.1
Coordinates 2206028..2206210 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285IZU0
Locus tag PCAU_RS10330 Protein ID WP_007923747.1
Coordinates 2205591..2205992 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCAU_RS10310 2201467..2203356 + 1890 WP_096373665.1 PAS domain S-box protein -
PCAU_RS10315 2203353..2203988 + 636 WP_096373666.1 response regulator transcription factor -
PCAU_RS10320 2204081..2204845 + 765 WP_096373667.1 hypothetical protein -
PCAU_RS10330 2205591..2205992 - 402 WP_007923747.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PCAU_RS10335 2206028..2206210 - 183 WP_009048155.1 type II toxin-antitoxin system HicA family toxin Toxin
PCAU_RS10340 2206573..2206854 - 282 WP_096373669.1 hypothetical protein -
PCAU_RS10345 2207278..2207655 - 378 WP_096373670.1 hypothetical protein -
PCAU_RS10350 2208408..2209319 + 912 WP_124344721.1 hypothetical protein -
PCAU_RS10355 2209641..2210117 - 477 WP_096373672.1 TIGR02391 family protein -
PCAU_RS32025 2210101..2210811 - 711 WP_124344722.1 DUF5343 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T30776 WP_009048155.1 NZ_AP014623:c2206210-2206028 [Pseudomonas chlororaphis subsp. aurantiaca]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

>T30776 NZ_AP014623:c2206210-2206028 [Pseudomonas chlororaphis subsp. aurantiaca]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGCAGCCATCATCTGTT
CAAGCATCCCTACCGGCCGGAGACCGTTCCAGTGCCTCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14579.54 Da        Isoelectric Point: 4.6017

>AT30776 WP_007923747.1 NZ_AP014623:c2205992-2205591 [Pseudomonas chlororaphis subsp. aurantiaca]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT30776 NZ_AP014623:c2205992-2205591 [Pseudomonas chlororaphis subsp. aurantiaca]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAGCACACTGCTACCGGCATCCAGATTCCTGACATTCCTGGCGCGGT
CACCGCCGGCGACACCTTCGAGGCCGCGTACAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAACTGGCCCGTG
AGGGGCAAGCCATTCCCCTGCCCTCACCCACCGGCACACACCGCGCCAACCCCGACTTCGAAGGGATGGGCTGGGGCATG
CTGGATATCGATATCACGCCTTACCTGGGCAAAACCGAAAAGGTCAATGTGACCCTGCCGGGCTACGTGATTCAACGAAT
CGACCGCTTTGTGCGGGAGCACAACATCAAGAGCCGGTCGTCTTTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7DMG3

Antitoxin

Source ID Structure
AlphaFold DB A0A285IZU0

References