Detailed information of TA system TA030763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 715280..715866
• Replicon: chromosome
• Accession: NZ_AP014612
• Organism: Streptococcus troglodytae strain TKU 31

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SRT_RS03645
• Protein ID: WP_128833074.1
• Coordinates: 715280..715471 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SRT_RS03650
• Protein ID: WP_128833075.1
• Coordinates: 715489..715866 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SRT_RS03630	710538..711446	+	909	WP_128833072.1	type II CRISPR-associated endonuclease Cas1	-
SRT_RS03635	711449..711772	+	324	WP_128833073.1	CRISPR-associated endonuclease Cas2	-
SRT_RS03640	711769..712817	+	1049	Protein_661	CRISPR-associated protein Cas7	-
SRT_RS03645	715280..715471	+	192	WP_128833074.1	type II toxin-antitoxin system HicA family toxin	Toxin
SRT_RS03650	715489..715866	+	378	WP_128833075.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SRT_RS03655	716134..717027	-	894	WP_161940020.1	XRE family transcriptional regulator	-
SRT_RS03660	717372..717625	+	254	Protein_665	helix-turn-helix transcriptional regulator	-
SRT_RS03665	717788..719539	+	1752	WP_128833076.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-107)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7123.47 Da
• Isoelectric Point: 10.7877

>T30763 WP_128833074.1 NZ_AP014612:715280-715471 [Streptococcus troglodytae]
MPLTGKELAKLAINNGWEEVRVRGSHHHFKKDGVPHIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T30763 NZ_AP014612:715280-715471 [Streptococcus troglodytae]
TTGCCATTAACAGGGAAAGAATTAGCTAAATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTACCTCATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14308.30 Da
• Isoelectric Point: 4.5628

>AT30763 WP_128833075.1 NZ_AP014612:715489-715866 [Streptococcus troglodytae]
MLKTYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
SPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALERKLQL

Nucleotide

• Length: 378 bp

>AT30763 NZ_AP014612:715489-715866 [Streptococcus troglodytae]
ATGTTAAAAACATATCCTGCAATTTTTCATAAGGAAGAGGAAGGGTATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTATTGGCCTCCTATCTAGATGAGG
GGATGAAACTGCCTAATCCAAGTGAGATAAGGAAACTATCTGTTGAAGATGGCTTTGCAACTATGATTCAAGCTGATCCT
AGCCCTTATCTCAAAAATAATAAAGCTATTCGGAAAAATGTGACAGTTCCTGAATGGCTGGTACAATTAGCAGATCGTGA
TCAAGTGAATTATTCTGAAGTATTAACAAAAGCTTTGGAAAGGAAACTACAATTATAA