Detailed information of TA system TA030761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2521815..2522476
• Replicon: chromosome
• Accession: NZ_AP014582
• Organism: Bordetella bronchiseptica strain S798

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: BBS798_RS11740
• Protein ID: WP_003812073.1
• Coordinates: 2521815..2522240 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BBS798_RS11745
• Protein ID: WP_003812071.1
• Coordinates: 2522237..2522476 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBS798_RS11720	2517629..2518606	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
BBS798_RS11725	2518627..2519139	-	513	WP_003812080.1	hypothetical protein	-
BBS798_RS11730	2519638..2521143	+	1506	WP_003812078.1	tripartite tricarboxylate transporter permease	-
BBS798_RS11735	2521241..2521705	-	465	WP_003812075.1	MarR family transcriptional regulator	-
BBS798_RS11740	2521815..2522240	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
BBS798_RS11745	2522237..2522476	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
BBS798_RS11750	2522550..2523392	-	843	WP_003812068.1	AraC family transcriptional regulator	-
BBS798_RS11755	2523530..2524075	+	546	WP_033452198.1	peroxidase-related enzyme	-
BBS798_RS11760	2524134..2524646	+	513	WP_003812062.1	redoxin domain-containing protein	-
BBS798_RS11765	2524727..2524960	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
BBS798_RS11770	2524957..2525517	+	561	WP_033452199.1	DUF488 domain-containing protein	-
BBS798_RS11775	2525595..2526641	+	1047	WP_003812057.1	Dyp-type peroxidase	-
BBS798_RS11780	2526638..2527441	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T30761 WP_003812073.1 NZ_AP014582:c2522240-2521815 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T30761 NZ_AP014582:c2522240-2521815 [Bordetella bronchiseptica]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCTCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT30761 WP_003812071.1 NZ_AP014582:c2522476-2522237 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT30761 NZ_AP014582:c2522476-2522237 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5